Prognostic and predictive value of immunological parameters for chemoradioimmunotherapy in patients with pancreatic adenocarcinoma

• Verfasst von: Karakhanova, Svetlana [VerfasserIn]
• Verfasst von: Ryschich, Eduard [VerfasserIn]
• Verfasst von: Mosl, Beate [VerfasserIn]
• Verfasst von: Harig, Sabine [VerfasserIn]
• Verfasst von: Jäger, Dirk [VerfasserIn]
• Verfasst von: Schmidt, Jan [VerfasserIn]
• Verfasst von: Bazhin, Alexandr V. [VerfasserIn]
• Titel: Prognostic and predictive value of immunological parameters for chemoradioimmunotherapy in patients with pancreatic adenocarcinoma
• Verf.angabe: S. Karakhanova, E. Ryschich, B. Mosl, S. Harig, D. Jäger, J. Schmidt, W. Hartwig, J. Werner, and A. V. Bazhin
• E-Jahr: 2015
• Jahr: 5 March 2015
• Umfang: 10 S.
• Fussnoten: Gesehen am 28.08.2017
• Titel Quelle: Enthalten in: British journal of cancer
• Ort Quelle: Edinburgh : Nature Publ. Group, 1999
• Jahr Quelle: 2015
• Band/Heft Quelle: 112(2015), 6, Seite 1027-1036
• ISSN Quelle: 1532-1827
• DOI: doi:10.1038/bjc.2015.72
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1562772120

Abstract

Background: Chemoradioimmunotherapy of patients with pancreatic adenocarcinoma from the CapRI trial did not show any benefit of interferon-α in addition to a 5-fluorouracil (5FU)-based treatment. The aim of this study was to identify immunological parameters in patients from this trial to be used for predictive and/or prognostic purposes. Methods: The following methods were used: tumour immunohistology, FACS analyses, cytokine measurement, as well as cytotoxicity and ELIspot. Immunological parameters were correlated with patients' survival using the Kaplan-Meier method. Results: Irrespective of therapy type, high lymphocyte accumulation in tumours and frequencies of NK cells and effector (eff) CD8+ T cells in peripheral blood of the patients were associated with patients' survival. Amount of CD3+ and effector-memory CD8+ blood lymphocytes, expression of CD152 and interleukin (IL)-2 serum level showed a predictive value for chemoradioimmunotherapy. Tumoural accumulation of CD3+ and CD8+ cells was predictive for outcome of chemotherapy alone. Besides, we identified the frequencies of CD3+ lymphocytes, effCD8+ T cells and NK cells in the peripheral blood of the patients, and IL-10 amount in serum, to be predictive values for 5FU-based chemotherapy. Conclusions: Immunological parameters, identified in this trial as possible markers, may be of interest in personalized medicine towards the improvement of the treatment and prognosis of pancreatic carcinoma patients.