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| Verfasst von: | Schölch, Sebastian [VerfasserIn]  |
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| | Rauber, Conrad [VerfasserIn] |
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| | Tietz-Dalfuß, Alexandra [VerfasserIn] |
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| | Schmidt, Thomas [VerfasserIn] |
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| | Haberkorn, Uwe [VerfasserIn] |
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| | Huber, Peter E. [VerfasserIn] |
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| Titel: | Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors |
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| Verf.angabe: | Sebastian Schölch, Conrad Rauber, Alexandra Tietz, Nuh N. Rahbari, Ulrich Bork, Thomas Schmidt, Christoph Kahlert, Uwe Haberkorn, Mark A. Tomai, Kenneth E. Lipson, Rafael Carretero, Jürgen Weitz, Moritz Koch and Peter E. Huber |
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| E-Jahr: | 2015 |
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| Jahr: | December 31, 2014 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 30.08.2017 |
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| Titel Quelle: | Enthalten in: OncoTarget |
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| Ort Quelle: | [S.l.] : Impact Journals LLC, 2010 |
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| Jahr Quelle: | 2015 |
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| Band/Heft Quelle: | 6(2015), 7, Seite 4663-4676 |
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| ISSN Quelle: | 1949-2553 |
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| Abstract: | In addition to local cytotoxic activity, radiotherapy may also elicit local and systemic antitumor immunity, which may be augmented by immunotherapeutic agents including Toll-like receptor (TLR) 7/8 agonists. Here, we investigated the ability of 3M-011 (854A), a TLR7/8 agonist, to boost the antigen-presenting activity of dendritic cells (DC) as an adjuvant to radiotherapy. The combined treatment induced marked local and systemic responses in subcutaneous and orthotopic mouse models of colorectal and pancreatic cancer. In vitro cytotoxicity assays as well as in vivo depletion experiments with monoclonal antibodies identified NK and CD8 T cells as the cell populations mediating the cytotoxic effects of the treatment, while in vivo depletion of CD11c+ dendritic cells (DC) in CD11c-DTR transgenic mice revealed DC as the pivotal immune hub in this setting. The specificity of the immune reaction was confirmed by ELISPOT assays. TLR7/8 agonists therefore seem to be potent adjuvants to radiotherapy, inducing strong local and profound systemic immune responses to tumor antigens released by conventional therapy. |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Kostenfrei: Volltext ; Verlag: http://dx.doi.org/undefined |
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| | Kostenfrei: Volltext: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467106/ |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1562893653 |
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| Verknüpfungen: | → Zeitschrift |
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Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors / Schölch, Sebastian [VerfasserIn]; December 31, 2014 (Online-Ressource)
