Status: Bibliographieeintrag
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| Online-Ressource |
Verfasst von: | Strube, Wolfgang [VerfasserIn]  |
| Rietschel, Marcella [VerfasserIn]  |
Titel: | BDNF-Val66Met-polymorphism impact on cortical plasticity in schizophrenia patients |
Titelzusatz: | a proof-of-concept study |
Verf.angabe: | Wolfgang Strube, MD; Michael A. Nitsche, MD; Thomas Wobrock, MD; Tilmann Bunse, MD; Bettina Rein, MD; Maximiliane Herrmann, MD; Andrea Schmitt, MD; Vanessa Nieratschker, PhD; Stephanie H. Witt, PhD; Marcella Rietschel, MD; Peter Falkai, MD; Alkomiet Hasan, MD |
E-Jahr: | 2015 |
Jahr: | 21 January 2015 |
Umfang: | 11 S. |
Fussnoten: | Gesehen am 01.09.2017 |
Titel Quelle: | Enthalten in: The international journal of neuropsychopharmacology |
Ort Quelle: | Oxford : Oxford Univ. Press, 1998 |
Jahr Quelle: | 2015 |
Band/Heft Quelle: | 18(2015), 4, Seite 1-11 |
ISSN Quelle: | 1469-5111 |
Abstract: | Background:Brain-derived neurotrophic factor (BDNF) has been shown to be a moderator of neuroplasticity. A frequent BDNF-polymorphism (Val66Met) is associated with impairments of cortical plasticity. In patients with schizophrenia, reduced neuroplastic responses following non-invasive brain stimulation have been reported consistently. Various studies have indicated a relationship between the BDNF-Val66Met-polymorphism and motor-cortical plasticity in healthy individuals, but schizophrenia patients have yet to be investigated. The aim of this proof-of-concept study was, therefore, to test the impact of the BDNF-Val66Met-polymorphism on inhibitory and facilitatory cortical plasticity in schizophrenia patients.Methods:Cortical plasticity was investigated in 22 schizophrenia patients and 35 healthy controls using anodal and cathodal transcranial direct-current stimulation (tDCS) applied to the left primary motor cortex. Animal and human research indicates that excitability shifts following anodal and cathodal tDCS are related to molecular long-term potentiation and long-term depression. To test motor-cortical excitability before and after tDCS, well-established single- and paired-pulse transcranial magnetic stimulation protocols were applied.Results:Our analysis revealed increased glutamate-mediated intracortical facilitation in met-heterozygotes compared to val-homozygotes at baseline. Following cathodal tDCS, schizophrenia met-heterozygotes had reduced gamma-amino-butyric-acid-mediated short-interval intracortical inhibition, whereas healthy met-heterozygotes displayed the opposite effect. The BDNF-Val66Met-polymorphism did not influence single-pulse motor-evoked potential amplitudes after tDCS.Conclusions:These preliminary findings support the notion of an association of the BDNF-Val66Met-polymorphism with observable alterations in plasticity following cathodal tDCS in schizophrenia patients. This indicates a complex interaction between inhibitory intracortical interneuron-networks, cortical plasticity, and the BDNF-Val66Met-polymorphism. Further replication and validation need to be dedicated to this question to confirm this relationship. |
DOI: | doi:10.1093/ijnp/pyu040 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: http://dx.doi.org/10.1093/ijnp/pyu040 |
| kostenfrei: Volltext: https://academic-oup-com.ezproxy.medma.uni-heidelberg.de/ijnp/article/18/4/pyu040/663472/BDNF-Val66Met-Polymorphism-Impa ... |
| DOI: https://doi.org/10.1093/ijnp/pyu040 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1562973282 |
Verknüpfungen: | → Zeitschrift |
BDNF-Val66Met-polymorphism impact on cortical plasticity in schizophrenia patients / Strube, Wolfgang [VerfasserIn]; 21 January 2015 (Online-Ressource)
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