Anastomotic leakage after curative rectal cancer resection has no impact on long-term survival

• Verfasst von: Ebinger, Sabrina Maria [VerfasserIn]
• Verfasst von: Warschkow, René [VerfasserIn]
• Verfasst von: Tarantino, Ignazio [VerfasserIn]
• Verfasst von: Schmied, Bruno [VerfasserIn]
• Verfasst von: Marti, Lukas [VerfasserIn]
• Titel: Anastomotic leakage after curative rectal cancer resection has no impact on long-term survival
• Titelzusatz: a propensity score analysis
• Verf.angabe: Sabrina M. Ebinger, René Warschkow, Ignazio Tarantino, Bruno M. Schmied, Lukas Marti
• E-Jahr: 2015
• Jahr: 06 August 2015
• Umfang: 9 S.
• Fussnoten: Gesehen am 07.09.2017
• Titel Quelle: Enthalten in: International journal of colorectal disease
• Ort Quelle: Berlin : Springer, 1986
• Jahr Quelle: 2015
• Band/Heft Quelle: 30(2015), 12, Seite 1667-1675
• ISSN Quelle: 1432-1262
• DOI: doi:10.1007/s00384-015-2331-6
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1563283123

Abstract

PurposeAnastomotic leakage (AL) is a severe and frequent complication of rectal cancer resection, with an incidence rate of approximately 9 %. Although the impact of AL on morbidity and short-term mortality has been established, the literature is contradictory regarding its influence on long-term, cancer-specific survival. The present investigation assessed the long-term survival of 584 patients with stage I-III rectal cancer.MethodsThe 10-year overall survival and cancer-specific survival were analyzed in 584 patients from a single tertiary center. All patients had undergone curative rectal cancer resection between 1991 and 2010. Patients with and without AL were compared using both a multivariate Cox hazards model and propensity score analysis.ResultsA total of 64 patients developed AL (11.0 %, 95 % confidence interval (CI) = 8.7 to 13.8 %). The median follow-up was 5.2 years for all patients; and 7.4 years for patients still alive at the end of the investigated period. AL did persistently not impair cancer-specific survival based on unadjusted Cox regression (hazard ratio of death (HR) = 1.27, 95 % CI = 0.65 to 2.48, P = 0.489); risk-adjusted Cox regression (HR = 1.10, 95 % CI = 0.54 to 2.20, P = 0.799); and propensity score matching (HR = 1.18, 95 % CI = 0.57 to 2.43, P = 0.660).ConclusionsBased on the present propensity score analysis, the oncologic outcomes in patients undergoing curative rectal cancer resections were not impaired by the development of anastomotic leakage.