Status: Bibliographieeintrag
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| |  Online-Ressource |
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| Verfasst von: | Claus, Ralf [VerfasserIn]  |
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| | Russwurm, Stefan [VerfasserIn] |
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| | Meisner, M. [VerfasserIn] |
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| | Kinscherf, Ralf [VerfasserIn] |
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| | Deigner, Hans-Peter [VerfasserIn] |
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| Titel: | Modulation of the ceramide level, a novel therapeutic concept |
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| Verf.angabe: | R. Claus, S. Russwurm, M. Meisner, R. Kinscherf, and H.P. Deigner |
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| E-Jahr: | 2000 |
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| Jahr: | 1 September 2000 |
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| Umfang: | 21 S. |
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| Fussnoten: | Gesehen am 13.09.2017 |
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| Titel Quelle: | Enthalten in: Current drug targets |
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| Ort Quelle: | Hilversum : Bentham Science Publ., 2000 |
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| Jahr Quelle: | 2000 |
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| Band/Heft Quelle: | 1(2000), 2, Seite 185-205 |
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| ISSN Quelle: | 1873-5592 |
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| Abstract: | The sphingomyelin (SM) pathway is an ubiquitous and evolutionarily conserved signaling system in which ceramide (CA), generated from SM by the action of various isoforms of sphingomyelinases (SMases) functions as an important second messenger. Recent evidence suggests that branching pathways of sphingolipid metabolism mediate either apoptotic or mitogenic responses depending on cell type and the nature of the stimulus. Events involving SM metabolites and CA in particular include proliferation differentiation and growth arrest as well as the induction of apoptosis. An improved understanding of SMase-dependent signaling may afford relevant insights into the pathogenesis of diseases and provide novel strategies and selective targets for a therapeutic intervention e.g. in cancer, cardiovascular and neurodegenerative diseases, HIV and septic shock. This article briefly summarizes the role of SMases in signaling pathways, its potential contribution in the development and maintenance of various pathobiological states and analyzes the perspective of a potentially isotype-specifc inhibition of S Mases as a novel therapeutic |
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| DOI: | doi:10.2174/1389450003349272 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.2174/1389450003349272 |
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| | DOI: https://doi.org/10.2174/1389450003349272 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Ceramide CA |
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| | Enzyme |
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| | HIV Infection |
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| | Metabolic |
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| | Metabolites |
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| | September 2000 |
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| | Sphinomyelin |
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| | TGF |
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| K10plus-PPN: | 1563460203 |
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| Verknüpfungen: | → Zeitschrift |
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Modulation of the ceramide level, a novel therapeutic concept / Claus, Ralf [VerfasserIn]; 1 September 2000 (Online-Ressource)
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