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Verfasst von:Arif, Rawa [VerfasserIn]   i
 Farag, Mina [VerfasserIn]   i
 Seppelt, Philipp [VerfasserIn]   i
 Beller, Carsten J. [VerfasserIn]   i
 Ruhparwar, Arjang [VerfasserIn]   i
 Karck, Matthias [VerfasserIn]   i
 Kallenbach, Klaus [VerfasserIn]   i
Titel:Patients with systemic lupus erythematosus and antiphospholipid syndrome undergoing cardiac valve surgery
Verf.angabe:Rawa Arif, Mina Farag, Philipp Seppelt, Carsten J. Beller, Arjang Ruhparwar, Matthias Karck, Klaus Kallenbach
Jahr:2015
Umfang:8 S.
Fussnoten:Gesehen am 20.09.2017
Titel Quelle:Enthalten in: The journal of heart valve disease
Ort Quelle:Northwood : ICR Publ., 1999
Jahr Quelle:2015
Band/Heft Quelle:24(2015), 2, Seite 228-235
ISSN Quelle:2053-2644
Abstract:BACKGROUND AND AIM OF THE STUDY: Systemic lupus erythematosus (SLE) and primary/secondary antiphospholipid syndrome (APLS) may cause early degenerative changes in cardiac valves, such as Libman-Sacks endocarditis, though few reports exist of this condition. Herein are presented the early and late clinical outcomes after cardiac valve surgery in patients diagnosed with SLE and APLS in a single-center experience. METHODS: A prospective analysis was conducted of the perioperative and follow up data acquired from patients with diagnosed SLE, and primary and secondary APLS, who underwent either single or combined valve surgery at the authors' department between 2002 and 2014. RESULTS: Fifteen patients (14 females, one male; mean age 53 ± 16 years; range: 16-77 years) were identified. The mean follow up time was 49 ± 32 months (range: 12.5-119 months). Thirteen patients (11 females, two males) were diagnosed with SLE; one of these patients had tricuspid Libman-Sacks endocarditis, while two female patients had primary APLS and four had secondary APLS. Besides bioprosthetic and mechanical valve replacements, mitral and tricuspid valve reconstruction were performed. The mean cross-clamp time was 112 ± 73 min (range: 55-294 min). Early major cardiovascular events occurred in two patients, and late non-fatal events in four patients, including one thromboembolic event. The 30-day and in-hospital mortalities were both 0%. Currently, 12 patients (80%) are alive at the end of follow up. Actuarial survival was 92 ± 7.4% at one year, 74 ± 18% at four years, and 49 ± 23% at ten years. CONCLUSION: Despite general concerns, the present results confirmed that patients with SLE and APLS can be operated on for cardiac valve disease, with favorable early results and acceptable long-term outcome.
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adolescent
 Adult
 Aged
 Antiphospholipid Syndrome
 Cardiac Surgical Procedures
 Female
 Heart Valve Diseases
 Heart Valve Prosthesis
 Heart Valve Prosthesis Implantation
 Humans
 Lupus Erythematosus, Systemic
 Middle Aged
 Oligopeptides
 Postoperative Complications
 Treatment Outcome
 Young Adult
K10plus-PPN:1563680726
Verknüpfungen:→ Zeitschrift

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