Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| Online-Ressource |
Verfasst von: | Hong, Gun-Soo [VerfasserIn]  |
| Hentschel, Frank [VerfasserIn]  |
Titel: | Gene variations in GSTM3 are a risk factor for Alzheimer's disease |
Verf.angabe: | G.-S. Hong, R. Heun, F. Jessen, J. Popp, F. Hentschel, P. Kelemen, A. Schulz, W. Maier, H. Kölsch |
E-Jahr: | 2009 |
Jahr: | [May 2009] |
Umfang: | 6 S. |
Illustrationen: | Illustrationen |
Fussnoten: | Gesehen am 05.10.2017 |
Titel Quelle: | Enthalten in: Neurobiology of aging |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1980 |
Jahr Quelle: | 2009 |
Band/Heft Quelle: | 30(2009), 5, Seite 691-696 |
ISSN Quelle: | 1558-1497 |
Abstract: | Oxidative stress is a relevant pathomechanism in Alzheimer's disease (AD) and gene variations in the glutathione S-transferase M3 gene (GSTM3), involved in the detoxification of oxygen radicals, might influence the risk of AD. We investigated the effect of three polymorphisms in GSTM3: rs1332018 (C/A); rs1799735 (del/AGG); rs7483 (G/A), on the risk of AD in 363 AD patients and 358 healthy controls. Single marker association analyses revealed that the AGG/AGG genotype of the GSTM3 rs1799735 (del/AGG) polymorphism was associated with an increased risk of AD (p=0.05), especially in the group of APOE4-allele non-carriers (p=0.004; OR=2.07). Examination of the haplotypes identified a two-marker haplotype (C/AGG) consisting of rs1332018 (C/A) and rs1799735 (del/AGG) to increase the risk of AD (p=0.029), this effect was also most prevalent in APOE4-allele non-carriers (p=0.009; OR=1.95). The population attributable risk of this haplotype in APOE4-allele non-carriers was 32.2%. Our results suggest that there is a group of AD patients in which variations in metabolism of oxidative stress play an important role. |
DOI: | doi:10.1016/j.neurobiolaging.2007.08.012 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.neurobiolaging.2007.08.012 |
| Volltext: http://www.sciencedirect.com/science/article/pii/S0197458007003466 |
| DOI: https://doi.org/10.1016/j.neurobiolaging.2007.08.012 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Alzheimer's disease |
| Genetic risk factor |
| GSTM3 |
| Oxidative stress |
K10plus-PPN: | 1564088502 |
Verknüpfungen: | → Zeitschrift |
Gene variations in GSTM3 are a risk factor for Alzheimer's disease / Hong, Gun-Soo [VerfasserIn]; [May 2009] (Online-Ressource)
68175905