Gene variations in GSTM3 are a risk factor for Alzheimer's disease

• Verfasst von: Hong, Gun-Soo [VerfasserIn]
• Verfasst von: Hentschel, Frank [VerfasserIn]
• Titel: Gene variations in GSTM3 are a risk factor for Alzheimer's disease
• Verf.angabe: G.-S. Hong, R. Heun, F. Jessen, J. Popp, F. Hentschel, P. Kelemen, A. Schulz, W. Maier, H. Kölsch
• E-Jahr: 2009
• Jahr: [May 2009]
• Umfang: 6 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 05.10.2017
• Titel Quelle: Enthalten in: Neurobiology of aging
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1980
• Jahr Quelle: 2009
• Band/Heft Quelle: 30(2009), 5, Seite 691-696
• ISSN Quelle: 1558-1497
• DOI: doi:10.1016/j.neurobiolaging.2007.08.012
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Alzheimer's disease
• Sach-SW: Genetic risk factor
• Sach-SW: GSTM3
• Sach-SW: Oxidative stress
• K10plus-PPN: 1564088502

Abstract

Oxidative stress is a relevant pathomechanism in Alzheimer's disease (AD) and gene variations in the glutathione S-transferase M3 gene (GSTM3), involved in the detoxification of oxygen radicals, might influence the risk of AD. We investigated the effect of three polymorphisms in GSTM3: rs1332018 (C/A); rs1799735 (del/AGG); rs7483 (G/A), on the risk of AD in 363 AD patients and 358 healthy controls. Single marker association analyses revealed that the AGG/AGG genotype of the GSTM3 rs1799735 (del/AGG) polymorphism was associated with an increased risk of AD (p=0.05), especially in the group of APOE4-allele non-carriers (p=0.004; OR=2.07). Examination of the haplotypes identified a two-marker haplotype (C/AGG) consisting of rs1332018 (C/A) and rs1799735 (del/AGG) to increase the risk of AD (p=0.029), this effect was also most prevalent in APOE4-allele non-carriers (p=0.009; OR=1.95). The population attributable risk of this haplotype in APOE4-allele non-carriers was 32.2%. Our results suggest that there is a group of AD patients in which variations in metabolism of oxidative stress play an important role.