No association of Vitamin D pathway genetic variants with cancer risks in a population-based cohort of German older adults

• Verfasst von: Ordóñez Mena, José M. [VerfasserIn]
• Verfasst von: Schöttker, Ben [VerfasserIn]
• Verfasst von: Saum, Kai-Uwe [VerfasserIn]
• Verfasst von: Burwinkel, Barbara [VerfasserIn]
• Verfasst von: Brenner, Hermann [VerfasserIn]
• Titel: No association of Vitamin D pathway genetic variants with cancer risks in a population-based cohort of German older adults
• Verf.angabe: José Manuel Ordóñez-Mena, Ben Schöttker, Kai U. Saum, Bernd Holleczek, Barbara Burwinkel, Thomas J. Wang, and Hermann Brenner
• E-Jahr: 2017
• Jahr: September 2017
• Umfang: 3 S.
• Teil: volume:26
• Teil: year:2017
• Teil: number:9
• Teil: pages:1459-1461
• Teil: extent:3
• Fussnoten: Gesehen am 05.10.2017
• Titel Quelle: Enthalten in: Cancer epidemiology, biomarkers & prevention
• Ort Quelle: Philadelphia, Pa. : AACR, 1991
• Jahr Quelle: 2017
• Band/Heft Quelle: 26(2017), 9, Seite 1459-1461
• ISSN Quelle: 1538-7755
• DOI: doi:10.1158/1055-9965.EPI-17-0191
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1564102831

Abstract

Background: Several investigations assessed the association of vitamin D receptor (VDR) SNPs with cancer risk. Less is known about the implications of other vitamin D pathway SNPs on cancer risk. Methods: In a population-based cohort study of 9,949 German older adults, we used Cox regression to assess the association of 6 SNPs in the VDR, vitamin D-binding protein (GC), 7-dehydrocholesterol reductase (DHCR7), vitamin D 25-hydroxylase (CYP2R1), and vitamin D 24-hydroxylase (CYP24A1) genes with total and site-specific cancer incidence endpoints. Results: Overall, no association of SNPs with cancer incidence endpoints was observed, except for a genotype score based on SNPs associated with lower 25(OH)D, which was associated with higher lung cancer risk [HR, 1.20; 95% confidence intervals (CI), 1.03-1.39], although this was no longer significant after correcting for multiple testing. Conclusions: Our data provide little to no evidence of a major influence of vitamin D genetic predisposition on cancer risks. Impact: Large-scale genetic epidemiology consortia and meta-analysis of smaller published studies are needed to verify a potential modest influence of genetic variation in the association of vitamin D with the risk of cancer.