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Status: Bibliographieeintrag

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Verfasst von:Winkler, Eva C. [VerfasserIn]   i
 Wiemann, Stefan [VerfasserIn]   i
Titel:Findings made in gene panel to whole genome sequencing
Titelzusatz:data, knowledge, ethics - and consequences?
Verf.angabe:Eva C. Winkler and Stefan Wiemann
E-Jahr:2016
Jahr:08 Aug 2016
Umfang:12 S.
Fussnoten:Gesehen am 05.10.2017
Titel Quelle:Enthalten in: Expert review of molecular diagnostics
Ort Quelle:Abingdon : Taylor & Francis Group, 2001
Jahr Quelle:2016
Band/Heft Quelle:16(2016), 12, Seite 1259-1270
ISSN Quelle:1744-8352
Abstract:Introduction: Improvements in sequencing technologies have helped to refine diagnosis and patient stratification via molecular genetic testing for a number of conditions. Consequently, sequencing has increasingly entered clinical routine. Reduced cost, combined with enhanced throughput has helped to place sequencing also in the commercial market thus moving beyond particular indications. Diverse kinds of sequencing approaches are applied, ranging from gene panel to whole-genome sequencing. All these have proven successful in the identification of causal and therapeutically relevant alterations to the benefit of patients. However, a number of technical and ethical issues induce challenges that require their appreciation, societal discussion and consensual decision.Areas covered: In the following paper, advantages and disadvantages of different DNA sequencing strategies towards their application within and outside a clinical context are discussed particularly in the light of the incidence and impact genetic findings have at the personal as well as societal level.Expert commentary: We regard the comprehensive education of citizens about these challenges a prerequisite to reach a societal consensus on the exploitation of the huge opportunities while not neglecting the potential and real dangers that are associated with the resulting data.
DOI:doi:10.1080/14737159.2016.1212662
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1080/14737159.2016.1212662
 DOI: https://doi.org/10.1080/14737159.2016.1212662
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:additional findings
 consent
 ethics
 exome sequencing
 gene panel
 genetic variation
 Genome sequencing
K10plus-PPN:1564115259
Verknüpfungen:→ Zeitschrift

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