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Verfasst von:Nußhag, Christian [VerfasserIn]   i
 Weigand, Markus A. [VerfasserIn]   i
 Zeier, Martin [VerfasserIn]   i
 Morath, Christian [VerfasserIn]   i
 Brenner, Thorsten [VerfasserIn]   i
Titel:Issues of acute kidney injury staging and management in sepsis and critical illness
Titelzusatz:a narrative review
Verf.angabe:Christian Nusshag, Markus A. Weigand, Martin Zeier, Christian Morath and Thorsten Brenner
E-Jahr:2017
Jahr:28 June 2017
Umfang:25 S.
Fussnoten:Gesehen am 06.10.2017
Titel Quelle:Enthalten in: International journal of molecular sciences
Ort Quelle:Basel : Molecular Diversity Preservation International, 2000
Jahr Quelle:2017
Band/Heft Quelle:18(2017,7) Artikel-Nummer 1387, 25 Seiten
ISSN Quelle:1422-0067
 1661-6596
Abstract:Acute kidney injury (AKI) has a high incidence on intensive care units around the world and is a major complication in critically ill patients suffering from sepsis or septic shock. The short- and long-term complications are thereby devastating and impair the quality of life. Especially in terms of AKI staging, the determination of kidney function and the timing of dialytic AKI management outside of life-threatening indications are ongoing matters of debate. Despite several studies, a major problem remains in distinguishing between beneficial and unnecessary “early” or even harmful renal replacement therapy (RRT). The latter might prolong disease course and renal recovery. AKI scores, however, provide an insufficient outcome-predicting ability and the related estimation of kidney function via serum creatinine or blood urea nitrogen (BUN)/urea is not reliable in AKI and critical illness. Kidney independent alterations of creatinine- and BUN/urea-levels further complicate the situation. This review critically assesses the current AKI staging, issues and pitfalls of the determination of kidney function and RRT timing, as well as the potential harm reflected by unnecessary RRT. A better understanding is mandatory to improve future study designs and avoid unnecessary RRT for higher patient safety and lower health care costs.
DOI:doi:10.3390/ijms18071387
URL:kostenfrei: Volltext ; Verlag: http://dx.doi.org/10.3390/ijms18071387
 kostenfrei: Volltext: http://www.mdpi.com/1422-0067/18/7/1387
 DOI: https://doi.org/10.3390/ijms18071387
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:acute kidney injury
 biomarkers
 disease staging
 glomerular filtration rate
 renal replacement therapy
 timing
K10plus-PPN:1564158888
Verknüpfungen:→ Zeitschrift
 
 
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