Gender-related differences in pulmonary arterial hypertension targeted drugs administration

• Verfasst von: Marra, Alberto M. [VerfasserIn]
• Verfasst von: Benjamin, Nicola [VerfasserIn]
• Verfasst von: Eichstaedt, Christina [VerfasserIn]
• Verfasst von: Grünig, Ekkehard [VerfasserIn]
• Titel: Gender-related differences in pulmonary arterial hypertension targeted drugs administration
• Verf.angabe: Alberto M. Marra, Nicola Benjamin, Christina Eichstaedt, Andrea Salzano, Michele Arcopinto, Luna Gargani, Michele D́Alto, Paola Argiento, Lorenzo Falsetti, Paolo Di Giosia, Andrea M. Isidori, Francesco Ferrara, Eduardo Bossone, Antonio Cittadini, Ekkehard Grünig
• E-Jahr: 2016
• Jahr: 19 October 2016
• Umfang: 7 S.
• Fussnoten: Gesehen am 06.10.2017
• Titel Quelle: Enthalten in: Pharmacological research
• Ort Quelle: London : Academic Press, 1969
• Jahr Quelle: 2016
• Band/Heft Quelle: 114(2016), Supplement C, Seite 103-109
• ISSN Quelle: 1096-1186
• DOI: doi:10.1016/j.phrs.2016.10.018
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Female
• Sach-SW: Gender
• Sach-SW: Male
• Sach-SW: Pulmonary arterial hypertension
• Sach-SW: Risk stratification
• Sach-SW: Treatment
• K10plus-PPN: 1564151565

Abstract

During the last 15 years, a real “paradigm-shift” occurred, due to the development of PAH-targeted drugs, leading to crucial improvements in symptoms, exercise capacity, hemodynamics and outcome of PAH patients. In order to describe differences regarding epidemiology and therapy in PAH according to gender, we performed a review of the available literature in “PubMed” and “Web of Science” databases. In order to find relevant articles, we combined each of the following the keywords “pulmonary arterial hypertension”, “gender”, “sex”, “men”, “woman”, “male”, “female”, “phosphodiesterase inhibitors”, “endothelin receptor antagonists”, “prostanoids”. While there is a substantial agreement among epidemiological studies in reporting an increased prevalence of pulmonary arterial hypertension (PAH) among women, male PAH patients are affected by a higher impairment of the right ventricular function and consequently experience poorer outcomes. With regards to PAH-targeted drug administration, endothelin receptor antagonists (ERAs) and prostacyclin analogues (PC) show better treatment results in female PAH patients, while phosphodiesterase-5 inhibitors (PD5-I) seem to exert a more beneficial effect on male patients. However, to date no clear consensus could be formed by the available literature, which is constituted mainly by retrospective studies. Females with PAH are more prone to develop PAH, while males experience poorer outcomes. Females PAH might benefit more from ERAs and PC, while males seem to have more beneficial effects from PD5-I administration. However, more research is warranted in order to assess the most effective treatment for PAH patients according to gender.