Status: Bibliographieeintrag
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| Verfasst von: | Chrubasik, Sigrun [VerfasserIn]  |
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| | Sporer, Frank [VerfasserIn] |
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| | Dillmann-Marschner, Ruth [VerfasserIn] |
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| | Wink, Michael [VerfasserIn] |
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| Titel: | Physicochemical properties of harpagoside and its in vitro release from Harpagophytum procumbens extract tablets |
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| Verf.angabe: | S. Chrubasik, F. Sporer, R. Dillmann-Marschner, A. Friedmann and M. Wink |
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| Jahr: | 2000 |
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| Umfang: | 5 S. |
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| Fussnoten: | DOI fehlerhaft ; Gesehen am 09.10.2017 |
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| Titel Quelle: | Enthalten in: Phytomedicine |
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| Ort Quelle: | München [u.a.] : Elsevier, 1994 |
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| Jahr Quelle: | 2000 |
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| Band/Heft Quelle: | 6(2000), 6, Seite 469-473 |
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| ISSN Quelle: | 1618-095X |
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| Abstract: | The objective of this investigation was to characterize the active-component harpagoside of Harpagophytum extract from a physico-chemical perspective and to determine its in-vitro release from tablets according to DAB 1996. It was found that both pure harpagoside and harpagoside in Harpagophytum extract have an octanol-water distribution coefficient of approximately 4 which is neither dependent on temperature nor on pH. The mean harpagoside content in Harpagophytum tablets of Batch 9102 was 16.4 mg (S.D. 0.2; S.E. 0.03). Related to a tablet weight of 365 mg (100%), this corresponds to a haragoside content of 4.5% (S.D. 0.049; S.E. 0.006). On average the tablets disintegrate after 18 +/- 3 minutes (mean +/- SD). The tablets taken from Batch 9102 released the active component harpagoside well, with a t50 of 13.5 min, a t90 of 23 min and a t95 of 25 min in relation to 16.5 mg of harpagoside per dose. Harpagoside content decreased by about 10% in artificial gastric fluid within a period of 3 hours and remained stable in artificial intestinal fluid for a period of 6 hours. |
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| DOI: | doi:10.1016/S0944-7113(00)80076-8 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://ac.els-cdn.com/S0944711300800768/1-s2.0-S0944711300800768-main.pdf?_tid=e227d9ec-acc1-11e7-bca7-00000aab0f27&acd ... |
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| | DOI: https://doi.org/10.1016/S0944-7113(00)80076-8 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Analgesics |
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| | Chromatography, High Pressure Liquid |
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| | Glycosides |
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| | Half-Life |
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| | Plant Extracts |
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| | Pyrans |
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| | Tablets |
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| K10plus-PPN: | 1564168239 |
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| Verknüpfungen: | → Zeitschrift |
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Physicochemical properties of harpagoside and its in vitro release from Harpagophytum procumbens extract tablets / Chrubasik, Sigrun [VerfasserIn]; 2000 (Online-Ressource)
68176799
