Status: Bibliographieeintrag
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| Verfasst von: | Gao, Xu [VerfasserIn]  |
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| | Zhang, Yan [VerfasserIn] |
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| | Brenner, Hermann [VerfasserIn] |
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| Titel: | Associations of Helicobacter pylori infection and chronic atrophic gastritis with accelerated epigenetic ageing in older adults |
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| Verf.angabe: | Xu Gao, Yan Zhang and Hermann Brenner |
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| E-Jahr: | 2017 |
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| Jahr: | 12 September 2017 |
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| Umfang: | 4 S. |
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| Fussnoten: | Gesehen am 17.10.2017 |
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| Titel Quelle: | Enthalten in: British journal of cancer |
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| Ort Quelle: | Edinburgh : Nature Publ. Group, 1999 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 117(2017), 8, Seite 1211-1214 |
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| ISSN Quelle: | 1532-1827 |
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| Abstract: | Background: Helicobacter pylori (HP) infection and chronic atrophic gastritis (CAG) have shown strong associations with the development of gastric cancer. This study aimed to examine whether both risk factors are associated with accelerated epigenetic ageing, as determined by the ‘DNA methylation age’, in a population-based study of older adults (n=1477). Methods: Serological measurements of HP antibodies and pepsinogen I and II for CAG definition were obtained by ELISA kits. Whole blood DNA methylation profiles were measured by Illumina Human Methylation450K Beadchip. DNA methylation ages were calculated by two algorithms proposed by Horvath and Hannum et al. Results: After adjusting for potential covariates in linear regression models, we found that HP infection, infection with virulent HP strains (CagA+) and severe CAG were significantly associated with an increase in DNA methylation age by ~0.4, 0.6 and 1 year (all P-values <0.05), respectively. Conclusions: Our study indicates that both CagA+ HP infection and CAG go along with accelerated epigenetic ageing. |
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| DOI: | doi:10.1038/bjc.2017.314 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: http://dx.doi.org/10.1038/bjc.2017.314 |
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| | Volltext: http://www.nature.com/bjc/journal/v117/n8/full/bjc2017314a.html?foxtrotcallback=true |
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| | DOI: https://doi.org/10.1038/bjc.2017.314 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | chronic atrophic gastritis |
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| | DNA methylation age |
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| | epigenetic epidemiology |
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| | gastric cancer |
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| | Helicobacter pylori |
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| K10plus-PPN: | 1564499162 |
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| Verknüpfungen: | → Zeitschrift |
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Associations of Helicobacter pylori infection and chronic atrophic gastritis with accelerated epigenetic ageing in older adults / Gao, Xu [VerfasserIn]; 12 September 2017 (Online-Ressource)
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