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Verfasst von:Zöllner, Frank G. [VerfasserIn]   i
 Klotz, Sarah [VerfasserIn]   i
 Höger, Simone [VerfasserIn]   i
 Schad, Lothar R. [VerfasserIn]   i
Titel:Functional imaging of acute kidney injury at 3 Tesla
Titelzusatz:investigating multiple parameters using DCE-MRI and a two-compartment filtration model
Paralleltitel:Funktionale Bildgebung des akuten Nierenversagens bei 3 Tesla
Paralleltitelzusatz:Untersuchung verschiedener Parameter unter Nutzung von DCE-MRT und eines 2-Kompartment-Filtrationsmodells
Verf.angabe:Frank G. Zöllner, Fabian Zimmer, Sarah Klotz, Simone Hoeger, Lothar R. Schad
E-Jahr:2015
Jahr:March 2015
Umfang:8 S.
Fussnoten:Gesehen am 19.10.2017
Titel Quelle:Enthalten in: Zeitschrift für medizinische Physik
Ort Quelle:Amsterdam [u.a.] : Elsevier, 1990
Jahr Quelle:2015
Band/Heft Quelle:25(2015), 1, Seite 58-65
ISSN Quelle:1876-4436
Abstract:To investigate how MR-based parameters reflect functional changes in kidneys with acute kidney injury (AKI) using dynamic contrast enhanced MRI and a two-compartment renal filtration model. MRI data of eight male Lewis rats were analyzed retrospectively. Five animals were subjected to AKI, three native rats served as control. All animals underwent perfusion imaging by dynamic contrast-enhanced MRI. Renal blood volume, glomerular filtration rate (GFR) as well as plasma and tubular mean transit times were estimated from regions-of-interest drawn in the renal cortex. Differences between healthy kidneys and kidneys subjected to AKI were analyzed using a paired t-test. Significant differences between ischemic and healthy kidneys could only be detected for the glomerular filtration rate. For all other calculated parameters, differences were present, however not significant. In rats with AKI, average single kidney GFR was 0.66 ± 0.37ml/min for contralateral and 0.26 ± 0.12ml/ min for diseased kidneys (P = 0.0254). For the healthy control group, the average GFR was 0.39 ± 0.06ml/min and 0.41 ± 0.11ml/min, respectively. Differences between diseased kidneys of AKI rats and ipsilateral kidneys of the healthy control group were significant (P=0.0381). Significant differences of functional parameters reflecting damage of the renal tissue of kidneys with AKI compared to the contralateral, healthy kidneys could only be detected by GFR. GFR might be a useful parameter that allows for a spatially resolved detection of abnormal changes of renal tissue by AKI.
DOI:doi:10.1016/j.zemedi.2014.01.002
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.zemedi.2014.01.002
 Volltext: http://www.sciencedirect.com/science/article/pii/S0939388914000038
 DOI: https://doi.org/10.1016/j.zemedi.2014.01.002
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:2-compartment filtration model
 2-Kompartment-Modell
 acute kidney injury
 Akutes Nierenversagen
 DCE-MRI
 DCE-MRT
 Funktionale Nierenbildgebung
 GFR
 quantification
 Quantifikation
 Renal functional imaging
K10plus-PPN:1564569055
Verknüpfungen:→ Zeitschrift

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