L-5-hydroxytryptophan

• Verfasst von: Lysek, Nicola [VerfasserIn]
• Verfasst von: Kinscherf, Ralf [VerfasserIn]
• Verfasst von: Claus, Ralf [VerfasserIn]
• Verfasst von: Lindel, Thomas [VerfasserIn]
• Titel: L-5-hydroxytryptophan
• Titelzusatz: antioxidant and anti-apoptotic principle of the intertidal sponge Hymeniacidon heliophila
• Verf.angabe: Nicola Lysek, Ralf Kinscherf, Ralf Claus, and Thomas Lindel
• E-Jahr: 2014
• Jahr: 02.06.2014
• Jahr des Originals: 2003
• Umfang: 5 S.
• Fussnoten: Gesehen am 20.10.2017
• Titel Quelle: Enthalten in: Zeitschrift für Naturforschung / C
• Ort Quelle: Berlin : de Gruyter, 1973
• Jahr Quelle: 2003
• Band/Heft Quelle: 58(2003), 7/8, Seite 568-572
• ISSN Quelle: 1865-7125
• DOI: doi:10.1515/znc-2003-7-821
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Apoptosis
• Sach-SW: Antioxidant
• Sach-SW: Marine sponge
• K10plus-PPN: 1564612139

Abstract

The intertidal sponge Hymeniacidon heliophila which survives under intense sunlight contains the antioxidant amino acid l-5-hydroxytryptophan (ʟ-5-HTP) as major constituent. The content of ʟ-5-HTP was determined as (0.45 ± 0.23)% of the dry weight by quantitative NMR-spectroscopical analysis with an internal standard. Other known antioxidants such as flavonoids, carotenoids or tocopherol derivatives were absent. Both the oxidation potential and the concentration of ʟ-5-HTP in H. heliophila correspond to the values observed for flavonoids being major antioxidants in plants. It was shown that ʟ-5-HTP suppresses UVinduced apoptosis in human monocytes at the same concentrations as it occurs in the sponge tissue.