Interventions to increase antiretroviral adherence in sub-Saharan Africa

• Verfasst von: Bärnighausen, Till [VerfasserIn]
• Verfasst von: Chaiyachati, Krisda [VerfasserIn]
• Verfasst von: Chimbindi, Natsayi [VerfasserIn]
• Verfasst von: Newell, Marie-Louise [VerfasserIn]
• Titel: Interventions to increase antiretroviral adherence in sub-Saharan Africa
• Titelzusatz: a systematic review of evaluation studies
• Verf.angabe: Till Bärnighausen, Krisda Chaiyachati, Natsayi Chimbindi, Ashleigh Peoples, Jessica Haberer, Marie-Louise Newell
• Umfang: 10 S.
• Fussnoten: Gesehen am 24.10.2017
• Titel Quelle: Enthalten in: The lancet <London> / Infectious diseases
• Jahr Quelle: 2011
• Band/Heft Quelle: 11(2011), 12, S. 942-951
• ISSN Quelle: 1474-4457
• DOI: doi:10.1016/S1473-3099(11)70181-5
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1564736598

Abstract

Summary. The success of potent antiretroviral treatment for HIV infection is primarily determined by adherence. We systematically review the evidence of effectiveness of interventions to increase adherence to antiretroviral treatment in sub-Saharan Africa. We identified 27 relevant reports from 26 studies of behavioural, cognitive, biological, structural, and combination interventions done between 2003 and 2010. Despite study diversity and limitations, evidence suggests that treatment supporters, directly observed therapy, mobile-phone text messages, diary cards, and food rations can effectively increase adherence in sub-Saharan Africa. However, some interventions are unlikely to have large or lasting effects, and others are effective only in specific settings. These findings emphasise the need for more research, particularly for randomised controlled trials, to examine the effect of context and specific features of intervention content on effectiveness. Future work should assess intervention targeting and selection of interventions based on behavioural theories relevant to sub-Saharan Africa.