Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Pohlack, Sebastian [VerfasserIn]   i
 Ruttorf, Michaela [VerfasserIn]   i
 Schad, Lothar R. [VerfasserIn]   i
 Rietschel, Marcella [VerfasserIn]   i
 Flor, Herta [VerfasserIn]   i
Titel:Neural mechanism of a sex-specific risk variant for posttraumatic stress disorder in the type I receptor of the pituitary adenylate cyclase activating polypeptide
Verf.angabe:Sebastian T. Pohlack, Frauke Nees, Michaela Ruttorf, Raffaele Cacciaglia, Tobias Winkelmann, Lothar R. Schad, Stephanie H. Witt, Marcella Rietschel, and Herta Flor
E-Jahr:2015
Jahr:December 15
Umfang:8 S.
Fussnoten:Gesehen am 25.10.2017
Titel Quelle:Enthalten in: Biological psychiatry
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1985
Jahr Quelle:2015
Band/Heft Quelle:78(2015), 12, Seite 840-847
ISSN Quelle:1873-2402
Abstract:Posttraumatic stress disorder (PTSD) is a frequent anxiety disorder with higher prevalence rates in female patients than in male patients (2.5:1). Association with a single nucleotide polymorphism (rs2267735) in the gene ADCYAP1R1 encoding the type I receptor (PAC1-R) of the pituitary adenylate cyclase activating polypeptide has been reported with PTSD in female patients. We sought to identify the neural correlates of the described PAC1-R effects on associative learning. In a reverse genetic approach, we examined two independent healthy samples (N1 = 112, N2 = 73) using functional magnetic resonance imaging during cued and contextual fear conditioning. Skin conductance responses and verbal self-reports of arousal, valence, and contingency were recorded. We found that PAC1-R modulates the blood oxygenation level-dependent response of the hippocampus. Specifically, we observed decreased hippocampal activity during contextual, but not during cued, fear conditioning in female participants carrying the PAC1-R risk allele. We observed no significant differences in conditionability for skin conductance responses, verbal reports, or activation in other brain regions between the genotype groups in female participants. Our results suggest that impaired contextual conditioning in the hippocampal formation may mediate the association between PAC1-R and PTSD symptoms. Our findings potentially identify a missing link between the involvement of PAC1-R in PTSD and the well-established structural and functional hippocampal deficits in these patients.
DOI:doi:10.1016/j.biopsych.2014.12.018
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.biopsych.2014.12.018
 Volltext: http://www.sciencedirect.com/science/article/pii/S0006322315000025
 DOI: https://doi.org/10.1016/j.biopsych.2014.12.018
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Amygdala
 Fear conditioning
 Functional magnetic resonance imaging
 Hippocampus
 PTSD
K10plus-PPN:1564765555
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68183605   QR-Code
zum Seitenanfang