A retinal snap shot may indicate individual risk for cardiovascular disease

• Verfasst von: Schuster, Alexander K. [VerfasserIn]
• Verfasst von: Fischer, Joachim E. [VerfasserIn]
• Verfasst von: Voßmerbäumer, Urs [VerfasserIn]
• Titel: A retinal snap shot may indicate individual risk for cardiovascular disease
• Titelzusatz: the MIPH Eye and Health Study
• Verf.angabe: Alexander Karl-Georg Schuster, Joachim Ernst Fischer, Urs Vossmerbaeumer
• E-Jahr: 2015
• Jahr: 1 February 2015
• Umfang: 4 S.
• Fussnoten: Gesehen am 26.10.2017
• Titel Quelle: Enthalten in: International journal of cardiology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1981
• Jahr Quelle: 2015
• Band/Heft Quelle: 180(2015), Seite 30-33
• ISSN Quelle: 1874-1754
• DOI: doi:10.1016/j.ijcard.2014.11.015
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: AV-ratio
• Sach-SW: Cardiovascular risk factor
• Sach-SW: Fundus photography
• Sach-SW: PROCAM
• Sach-SW: Refraction
• Sach-SW: retinal vessel
• Sach-SW: SCORE
• K10plus-PPN: 1564799743

Abstract

Examination of retinal vasculature can be used to non-invasively quantify changes within the microvasculature of the human body and might be a predictor of cardiovascular disease. This study evaluates associations of the structure of the retinal vasculature with established risk factors for cardiovascular disease. A cross-sectional study was performed in a working age population. Several systemic cardiovascular parameters were analyzed and PROCAM- and SCORE-risk estimates were calculated. A quantitative ophthalmological examination including digital fundus imaging has taken place. Central retinal arterial/venous equivalents (CRAE/CRVE) and arterio-venous ratio (AVR) were analyzed using validated software. Associations of retinal vessel parameters and systemic cardiovascular and ocular parameters were calculated by multivariate analysis using SPSS software. A p-value of <0.05 with Bonferroni correction was accepted as significant. 338 probands were included. A smaller CRAE was independently associated with increased mean arterial blood pressure, higher age and higher body-mass index. Regarding CRVE age was inversely associated. Other cardiovascular risk parameters were not associated to the examined retinal vessel equivalents. AVR showed a significant association to mean arterial blood pressure and body-mass-index. PROCAM- and SCORE-risk estimates were negatively associated with CRAE and AVR, but not associated to CRVE. Arterial retinal vessel analysis and AV-ratio showed associations to established cardiovascular parameters in the study population. PROCAM- and SCORE-risk estimates as indicators of cardiovascular risk were associated with the CRAE and the AV-ratio. This suggests that a single snap shot of the retinal vessels may indicate the individual relative risk for cardiovascular events.