Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Hertle, Daniel [VerfasserIn]   i
 Beynon, Christopher [VerfasserIn]   i
 Neumann, Jan-Oliver [VerfasserIn]   i
 Santos, Edgar [VerfasserIn]   i
 Sánchez-Porras, Renán [VerfasserIn]   i
 Unterberg, Andreas [VerfasserIn]   i
 Sakowitz, Oliver [VerfasserIn]   i
Titel:Use of GABAergic sedatives after subarachnoid hemorrhage is associated with worse outcome—preliminary findings
Verf.angabe:Daniel N. Hertle, Christopher Beynon, Jan O. Neumann, Edgar Santos, Renan Sánchez-Porras, Andreas W. Unterberg, Oliver W. Sakowitz
E-Jahr:2016
Jahr:11 August 2016
Umfang:5 S.
Fussnoten:Gesehen am 26.10.2017
Titel Quelle:Enthalten in: Journal of clinical anesthesia
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1988
Jahr Quelle:2016
Band/Heft Quelle:35(2016), Supplement C, Seite 118-122
ISSN Quelle:1873-4529
Abstract:Recent experimental evidence identified GABAergic sedation as a possible cause for deprived neuroregeneration and poor outcome after acute brain injury. Patients with aneurysmal subarachnoid hemorrhage are often sedated, and GABAergic sedation, such as midazolam and propofol, is commonly used. Retrospective cohort study based on a prospectively established database. Single-center neurointensive care unit. Twenty-nine patients after subarachnoid hemorrhage. Noninterventional study. The relationship between mean GABAergic sedative dose during the acute phase and outcome after 6 months according to the Glasgow Outcome Scale, and initial Glasgow Coma Scale was investigated. Use of GABAergic sedatives was negatively correlated with Glasgow Outcome Scale (r2=0.267; P=.008). Administration of sedatives was independent of the initial Glasgow Coma Scale. GABAergic sedatives flunitrazepam, midazolam, and propofol were used differently during the first 10 days after ictus. Administration of GABAergic sedation was associated with an unfavorable outcome after 6 months. To avoid bias (mainly through the indication to use sedation), additional experimental and comparative clinical investigation of, for example, non-GABAergic sedation, and clinical protocols of no sedation is necessary.
DOI:doi:10.1016/j.jclinane.2016.07.006
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1016/j.jclinane.2016.07.006
 Volltext: http://www.sciencedirect.com/science/article/pii/S0952818016303683
 DOI: https://doi.org/10.1016/j.jclinane.2016.07.006
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Midazolam
 Outcome
 Propofol
 SAH
 Sedation
K10plus-PPN:156482893X
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68184112   QR-Code
zum Seitenanfang