Regulatory function of CD4+CD25++ T cells in patients with myasthenia gravis is associated with phenotypic changes and STAT5 signaling

• Verfasst von: Alahgholi-Hajibehzad, Mahdi [VerfasserIn]
• Verfasst von: Marx, Alexander [VerfasserIn]
• Titel: Regulatory function of CD4+CD25++ T cells in patients with myasthenia gravis is associated with phenotypic changes and STAT5 signaling
• Titelzusatz: 1,25-Dihydroxyvitamin D3 modulates the suppressor activity
• Verf.angabe: Mahdi Alahgholi-Hajibehzad, Piraye Oflazer, Fikret Aysal, Hacer Durmuş, Yeşim Gülşen-Parman, Alexander Marx, Feza Deymeer, Güher Saruhan-Direskeneli
• E-Jahr: 2015
• Jahr: 15 April 2015
• Umfang: 10 S.
• Fussnoten: Gesehen am 02.11.2017 ; Im Titel sind „+” und "++" hochgestellt
• Titel Quelle: Enthalten in: Journal of neuroimmunology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1981
• Jahr Quelle: 2015
• Band/Heft Quelle: 281(2015), Seite 51-60
• ISSN Quelle: 1872-8421
• DOI: doi:10.1016/j.jneuroim.2015.03.008
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: GITR
• Sach-SW: LOMG
• Sach-SW: PD-1
• Sach-SW: STAT-5
• Sach-SW: Treg
• Sach-SW: Vitamin D
• K10plus-PPN: 1564931080

Abstract

Regulatory T cells were investigated in early-onset (EO) and late-onset (LO) myasthenia gravis patients with anti-acetylcholine receptor antibody (AChR-MG). Alterations in PD-1 and PD-L1 on CD4+CD25++ (Treg) and responder T cells (Tresp, CD4+CD25−) were observed in LOMG patients. GITR was decreased on CD4+CD25++ of all patients. Decrease of FOXP3 was associated with lower phosphorylation of STAT5.1,25-dihydroxyvitamin D3 (VitD3) increased suppression in co-culture with a stronger effect in patients by acting possibly both on cell groups. Changes in surface molecules and intracellular pathways contribute to the defects of Treg in non-thymomatous AChR-MG and VitD3 can have modulatory effects.