31P RINEPT MRSI and VBM reveal alterations in brain aging associated with major depression

• Verfasst von: Biedermann, Sarah Violetta [VerfasserIn]
• Verfasst von: Sartorius, Alexander [VerfasserIn]
• Verfasst von: Ende, Gabriele [VerfasserIn]
• Titel: 31P RINEPT MRSI and VBM reveal alterations in brain aging associated with major depression
• Verf.angabe: Sarah V. Biedermann, Wolfgang Weber-Fahr, Traute Demirakca, Nuran Tunc-Skarka, Mareen Hoerst, Fritz Henn, Alexander Sartorius, and Gabriele Ende
• E-Jahr: 2015
• Jahr: 5 May 2014
• Jahr des Originals: 2014
• Umfang: 11 S.
• Fussnoten: Gesehen am 02.11.2017 ; Im Titel ist „31” hochgestellt
• Titel Quelle: Enthalten in: Magnetic resonance in medicine
• Ort Quelle: New York, NY [u.a.] : Wiley-Liss, 1984
• Jahr Quelle: 2015
• Band/Heft Quelle: 73(2015), 4, Seite 1390-1400
• ISSN Quelle: 1522-2594
• DOI: doi:10.1002/mrm.25278
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: electroconvulsive therapy
• Sach-SW: Hippocampus
• Sach-SW: major depression
• Sach-SW: phosphorous magnetic resonance spectroscopy
• Sach-SW: refocused insensitive nuclei-enhanced polarization transfer
• Sach-SW: voxel based morphometry
• K10plus-PPN: 1564939197

Abstract

Purpose: Phosphomono- and diesters, the major components of the choline peak in 1H magnetic resonance spectroscopy, are associated with membrane anabolic and catabolic mechanisms. With the refocused insensitive nuclei-enhanced polarization transfer technique, these phospholipids are edited and enhanced in the 31P MR spectrum. In depressed patients, alterations of the choline peak and cerebral volume have been found, indicating a possible relation. Thus, combining MR phosphorous spectroscopy and volumetry in depressed patients seems to be a promising approach to detect underlying pathomechanisms. Methods: Depressed in-patients were either treated with antidepressive medication or with electroconvulsive therapy and compared to matched healthy controls. 31P magnetic resonance spectroscopy imaging was conducted before and after the treatment phases. A 3D MRI dataset for volumetry was acquired in a dedicated 1H head coil. Results: Phosphocholine and phosphoethanolamine were increased in depressed patients. Though patients responded to the treatments, phospholipids were not significantly altered. An increased age-related gray matter loss in fronto-limbic regions along with an altered relation of phosphomonoesters/phosphodiesters with age were found in depressed patients. Discussion: The findings of increased phosphomonoesthers and an age*group interaction for gray matter volumes need further research to define the role of phospholipids in major depression and possible associations to gray matter loss.