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Verfasst von:Bumb, Jan Malte [VerfasserIn]   i
 Janke, Christoph [VerfasserIn]   i
 Gass, Peter [VerfasserIn]   i
 Sartorius, Alexander [VerfasserIn]   i
Titel:Focus on ECT seizure quality
Titelzusatz:serum BDNF as a peripheral biomarker in depressed patients
Verf.angabe:Jan Malte Bumb, Suna Su Aksay, Christoph Janke, Laura Kranaster, Olga Geisel, Peter Gass, Rainer Hellweg, Alexander Sartorius
Jahr:2015
Umfang:6 S.
Fussnoten:Gesehen am 02.11.2017
Titel Quelle:Enthalten in: European archives of psychiatry and clinical neuroscience
Ort Quelle:Darmstadt : Steinkopff, 1868
Jahr Quelle:2015
Band/Heft Quelle:265(2015), 3, Seite 227-232
ISSN Quelle:1433-8491
Abstract:Electroconvulsive therapy (ECT) is a well-established, safe and effective treatment in severest or drug-resistant affective disorders. The potential relation between any peripheral biological marker and the seizure quality as a surrogate for treatment efficacy has not been investigated so far. We prospectively examined serum brain-derived neurotrophic factor (BDNF) levels in 20 patients with major depression before and after electroconvulsive therapy. A seizure quality sum score for every ECT session was build up on the basis of the seizure duration, seizure amplitude, central inhibition, interhemispheric coherence and sympathetic activation. Serum BDNF levels were significantly higher after ECT (P = 0.036). In the linear regression analysis, a significant correlation of the serum BDNF levels and the time between the last ECT and the blood withdrawal (P = 0.01) was observed. The ANOVA revealed a significant influence of the interval between the last ECT and the blood withdrawal (P = 0.0017) as well as the seizure quality (P = 0.038) on the variance of BDNF serum levels. Our data corroborate the neurotrophin hypothesis suggesting an ECT-induced central BDNF rise leading to a delayed (>6 days) and increased equilibrium of the peripheral BDNF. The association of seizure adequacy with a BDNF rise might underline the importance of monitoring seizure quality markers in daily practice.
DOI:doi:10.1007/s00406-014-0543-3
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1007/s00406-014-0543-3
 Volltext: https://link-springer-com.ezproxy.medma.uni-heidelberg.de/article/10.1007/s00406-014-0543-3
 DOI: https://doi.org/10.1007/s00406-014-0543-3
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1564950573
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