Predicting the response to intravenous immunoglobulins in an animal model of chronic neuritis

• Verfasst von: Meyer zu Hörste, Gerd [VerfasserIn]
• Verfasst von: Pfaff, Johannes [VerfasserIn]
• Verfasst von: Bendszus, Martin [VerfasserIn]
• Verfasst von: Pham, Mirko [VerfasserIn]
• Titel: Predicting the response to intravenous immunoglobulins in an animal model of chronic neuritis
• Verf.angabe: Gerd Meyer zu Horste, Steffen Cordes, Johannes Pfaff, Christian Mathys, Anne K. Mausberg, Martin Bendszus, Mirko Pham, Hans-Peter Hartung, Bernd C. Kieseier
• Fussnoten: Gesehen am 07.11.2017
• Titel Quelle: Enthalten in: Public Library of Science: PLoS one
• Jahr Quelle: 2016
• Band/Heft Quelle: 11(2016) Artikel-Nummer e0164099, 16 Seiten
• ISSN Quelle: 1932-6203
• DOI: doi:10.1371/journal.pone.0164099
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1565101685

Abstract

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a disabling autoimmune disorder of the peripheral nervous system (PNS). Intravenous immunoglobulins (IVIg) are effective in CIDP, but the treatment response varies greatly between individual patients. Understanding this interindividual variability and predicting the response to IVIg constitute major clinical challenges in CIDP. We previously established intercellular adhesion molecule (ICAM)-1 deficient non-obese diabetic (NOD) mice as a novel animal model of CIDP. Here, we demonstrate that similar to human CIDP patients, ICAM-1 deficient NOD mice respond to IVIg treatment by clinical and histological measures. Nerve magnetic resonance imaging and histology demonstrated that IVIg ameliorates abnormalities preferentially in distal parts of the sciatic nerve branches. The IVIg treatment response also featured great heterogeneity allowing us to identify IVIg responders and non-responders. An increased productionof interleukin (IL)-17 positively predicted IVIg treatment responses. In human sural nerve biopsy sections, high numbers of IL-17 producing cells were associated with younger age and shorter disease duration. Thus, our novel animal model can be utilized to identify prognostic markers of treatment responses in chronic inflammatory neuropathies and we identify IL-17 production as one potential such prognostic marker.