Low-dose budesonide treatment for prevention of postoperative recurrence of Crohn's disease

• Verfasst von: Ewe, Klaus [VerfasserIn]
• Verfasst von: Böttger, Thomas [VerfasserIn]
• Verfasst von: Buhr, Heinz J. [VerfasserIn]
• Verfasst von: Ecker, Karl-Wilhelm [VerfasserIn]
• Verfasst von: Otto, Herwart F. [VerfasserIn]
• Titel: Low-dose budesonide treatment for prevention of postoperative recurrence of Crohn's disease
• Titelzusatz: a multicentre randomized placebo-controlled trial
• Verf.angabe: Klaus Ewe, Thomas Böttger, Heinz J. Buhr, Karl-Wilhelm Ecker, Herwart F. Otto
• Umfang: 6 S.
• Fussnoten: Gesehen am 08.11.2017
• Titel Quelle: Enthalten in: European journal of gastroenterology & hepatology
• Jahr Quelle: 1999
• Band/Heft Quelle: 11(1999), 3, S. 277-282
• ISSN Quelle: 1473-5687
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1565160169

Abstract

Summary and Conclusion: Although the effect of budesonide was altogether positive in almost all variables studied in this train (e.g. endoscopic and histopathological score, time-to-failure, CDAI, patients' global judgement and rate of side effects), this increase in efficacy was small and the power for the detecting differences versus placebo was too low to be statistically significant. According to these results, low-dose oral budesonide cannot be recommended to be used for the prevention of postoperative relapse in Crohn's disease