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| Verfasst von: | Frölich, Lutz [VerfasserIn]  |
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| | Schröder, Johannes [VerfasserIn] |
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| | Henn, Fritz A. [VerfasserIn] |
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| Titel: | Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer’s dementia |
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| Verf.angabe: | Lutz Frölich, Oliver Peters, Piotr Lewczuk, Oliver Gruber, Stefan J. Teipel, Hermann J. Gertz, Holger Jahn, Frank Jessen, Alexander Kurz, Christian Luckhaus, Michael Hüll, Johannes Pantel, Friedel M. Reischies, Johannes Schröder, Michael Wagner, Otto Rienhoff, Stefanie Wolf, Chris Bauer, Johannes Schuchhardt, Isabella Heuser, Eckart Rüther, Fritz Henn, Wolfgang Maier, Jens Wiltfang and Johannes Kornhuber |
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| E-Jahr: | 2017 |
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| Jahr: | 10 October 2017 |
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| Fussnoten: | Gesehen am 09.11.2017 |
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| Titel Quelle: | Enthalten in: Alzheimer's research & therapy |
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| Ort Quelle: | London : BioMed Central, 2009 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 9(2017) Artikel-Nummer 84, 15 Seiten |
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| ISSN Quelle: | 1758-9193 |
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| Abstract: | The progression of mild cognitive impairment (MCI) to Alzheimer’s disease (AD) dementia can be predicted by cognitive, neuroimaging, and cerebrospinal fluid (CSF) markers. Since most biomarkers reveal complementary information, a combination of biomarkers may increase the predictive power. We investigated which combination of the Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR)-sum-of-boxes, the word list delayed free recall from the Consortium to Establish a Registry of Dementia (CERAD) test battery, hippocampal volume (HCV), amyloid-beta1-42 (Aβ42), amyloid-beta1-40 (Aβ40) levels, the ratio of Aβ42/Aβ40, phosphorylated tau, and total tau (t-Tau) levels in the CSF best predicted a short-term conversion from MCI to AD dementia. |
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| DOI: | doi:10.1186/s13195-017-0301-7 |
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| URL: | kostenfrei: Volltext: http://dx.doi.org/10.1186/s13195-017-0301-7 |
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| | kostenfrei: Volltext: https://doi.org/10.1186/s13195-017-0301-7 |
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| | DOI: https://doi.org/10.1186/s13195-017-0301-7 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Alzheimer’s dementia |
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| | Amyloid-beta 42 |
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| | biomarkers |
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| | Hippocampal volume |
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| | Mild cognitive impairment |
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| | Phospho-tau |
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| | Prediction |
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| | Tau |
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| K10plus-PPN: | 1565211774 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer’s dementia / Frölich, Lutz [VerfasserIn]; 10 October 2017 (Online-Ressource)
