Prevalence and clinical associations of PTEN loss in non-small cell lung carcinoma (NSCLC) patients (pts) of the European thoracic oncology platform (ETOP) lungscape cohort

• Verfasst von: Soltermann, Alex [VerfasserIn]
• Verfasst von: Warth, Arne [VerfasserIn]
• Titel: Prevalence and clinical associations of PTEN loss in non-small cell lung carcinoma (NSCLC) patients (pts) of the European thoracic oncology platform (ETOP) lungscape cohort
• Verf.angabe: A. Soltermann, U. Rulle, O. Dafni, E. Verbeken, E. Thunnissen, A. Warth, R. Cheney, A. Sejda, E.-J. Speel, L. Bille Madsen, D. Nonaka, A. Navarro, I. Sansano, A. Marchetti, S. Finn, R. Kammler, K. Schulze, L. Bubendorf, R.A. Stahel, O.B.O. Lungscape
• Fussnoten: Gesehen am 10.11.2016
• Titel Quelle: Enthalten in: Annals of oncology
• Jahr Quelle: 2016
• Band/Heft Quelle: 27(2016,Supplement 6) Artikel-Nummer 1525P, 1 Seite
• ISSN Quelle: 1569-8041
• DOI: doi:10.1093/annonc/mdw392.07
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1565247825

Abstract

© The Author 2016. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: [e-mail]: Loss of PTEN might be a prognostic biomarker in NSCLC.Methods: We explored the prevalence of PTEN loss and its association with clinico-pathologic parameters as well as patient outcome (overall survival (OS), relapse-free survival (RFS) and time to relapse (TTR)) in the ETOP Lungscape cohort of resected stages I-III NSCLC. Tumor tissue was assessed for PTEN protein expression using immunohistochemistry on tissue microarrays. All cases were locally H-scored by ETOP pathologists, after having passed a stringent External Quality Assessment, and were centrally analyzed with pixel-based Image-J computer analysis. PTEN loss was defined as H-score = 0.Results: PTEN expression in tumor tissue was evaluable in 2245 pts from 16 ETOP Lungscape centers with the following characteristics: median follow-up 4.8 years; 54.3% of pts...