Association of norepinephrine transporter (NET, SLC6A2) genotype with ADHD-related phenotypes

• Verfasst von: Hohmann, Sarah [VerfasserIn]
• Verfasst von: Schmidt, Martin H. [VerfasserIn]
• Verfasst von: Banaschewski, Tobias [VerfasserIn]
• Verfasst von: Brandeis, Daniel [VerfasserIn]
• Verfasst von: Laucht, Manfred [VerfasserIn]
• Titel: Association of norepinephrine transporter (NET, SLC6A2) genotype with ADHD-related phenotypes
• Titelzusatz: findings of a longitudinal study from birth to adolescence
• Verf.angabe: Sarah Hohmann, Erika Hohm, Jens Treutlein, Dorothea Blomeyer, Christine Jennen-Steinmetz, Martin H. Schmidt, Günter Esser, Tobias Banaschewski, Daniel Brandeis, Manfred Laucht
• E-Jahr: 2015
• Jahr: 30 April 2015
• Umfang: 9 S.
• Fussnoten: Gesehen am13.11.2017
• Titel Quelle: Enthalten in: Psychiatry research
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1979
• Jahr Quelle: 2015
• Band/Heft Quelle: 226(2015), 2-3, Seite 425-433
• ISSN Quelle: 1872-7123
• DOI: doi:10.1016/j.psychres.2014.12.029
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Attention-deficit/hyperactivity disorder
• Sach-SW: Continuous performance task
• Sach-SW: Genetic association
• Sach-SW: Molecular heterosis
• Sach-SW: Norepinephrine transporter
• Sach-SW: Polymorphism
• K10plus-PPN: 1565293827

Abstract

Variation in the gene encoding for the norepinephrine transporter (NET, SLC6A2) has repeatedly been linked with ADHD, although there is some inconsistency regarding the association with specific genes. The variants for which most consistent association has been found are the NET variants rs3785157 and rs28386840. Here, we tested for their association with ADHD diagnosis and ADHD-related phenotypes during development in a longitudinal German community sample. Children were followed from age 4 to age 15, using diagnostic interviews to assess ADHD. Between the ages of 8 and 15 years, the Child Behavior Checklist (CBCL) was administered to the primary caregivers. The continuous performance task (CPT) was performed at age 15. Controlling for possible confounders, we found that homozygous carriers of the major A allele of the functional promoter variant rs28386840 displayed a higher rate of ADHD lifetime diagnosis. Moreover, homozygous carriers of the minor T allele of rs3785157 were more likely to develop ADHD and showed higher scores on the CBCL externalizing behavior scales. Additionally, we found that individuals heterozygous for rs3785157 made fewer omission errors in the CPT than homozygotes. This is the first longitudinal study to report associations between specific NET variants and ADHD-related phenotypes during the course of development.