Management of chronic myeloid leukemia in blast crisis

• Verfasst von: Saußele, Susanne [VerfasserIn]
• Verfasst von: Silver, Richard T. [VerfasserIn]
• Titel: Management of chronic myeloid leukemia in blast crisis
• Verf.angabe: S. Saußele, Richard T. Silver
• E-Jahr: 2015
• Jahr: April 2015
• Umfang: 7 S.
• Fussnoten: Gesehen am 20.11.2017
• Titel Quelle: Enthalten in: Annals of hematology
• Ort Quelle: Berlin : Springer, 1991
• Jahr Quelle: 2015
• Band/Heft Quelle: 94(2015), Supplement 2, Seite S159-S165
• ISSN Quelle: 1432-0584
• DOI: doi:10.1007/s00277-015-2324-0
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 156549329X

Abstract

Due to the high efficacy of BCR-ABL tyrosine kinase inhibition (TKI) in chronic phase (CP) chronic myeloid leukemia (CML), the frequency of blast crisis (BC) is greatly reduced compared to the pre-TKI era. However, TKI treatment of BC has only marginally improved the number of favorable responses, including remissions, which for the most part have only been transitory. Occasionally, they provide a therapeutic window to perform an allogeneic stem cell transplantation (allo-SCT). The challenge remains to improve management of BC with the limited options available. We review and summarize articles pertaining to the treatment of BC CML published after 2002. Additionally, we will discuss whether there is a need for a new definition of BC and/or treatment failure.