Extracellular miRNA

• Verfasst von: Turchinovich, Andrey [VerfasserIn]
• Verfasst von: Tonevitsky, Alexander [VerfasserIn]
• Verfasst von: Burwinkel, Barbara [VerfasserIn]
• Titel: Extracellular miRNA
• Titelzusatz: a collision of two paradigms
• Verf.angabe: Andrey Turchinovich, Alexander G. Tonevitsky, Barbara Burwinkel
• E-Jahr: 2016
• Jahr: 3 September 2016
• Umfang: 10 S.
• Fussnoten: Gesehen am 01.12.2017
• Titel Quelle: Enthalten in: Trends in biochemical sciences
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1976
• Jahr Quelle: 2016
• Band/Heft Quelle: 41(2016), 10, Seite 883-892
• ISSN Quelle: 1362-4326
• DOI: doi:10.1016/j.tibs.2016.08.004
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1565941128

Abstract

Since their discovery in 2008, extracellular miRNAs (ex-miRNAs) have persisted as one of the major themes of molecular and cellular biology. The main reason for this remarkable interest is the increasing number of research papers reporting that cell-free circulating miRNA mediates both short-range and distant communication between various cells, and could impact on diverse physiological and pathological processes. However, there are also multiple conflicting lines of evidence that challenge the biological significance of circulating ex-miRNA, suggesting that they are merely byproducts of cell activity and cell death without any particular function. This review aims to summarize these contrasting opinions and to foster further experimental validation of both paradigms.