Comparison of livestock-associated and health care-associated MRSA

• Verfasst von: Mutters, Nico T. [VerfasserIn]
• Verfasst von: Bieber, Christian Paul [VerfasserIn]
• Verfasst von: Hauck, Catherine [VerfasserIn]
• Verfasst von: Malek, Veronika [VerfasserIn]
• Verfasst von: Frank, Uwe [VerfasserIn]
• Titel: Comparison of livestock-associated and health care-associated MRSA
• Titelzusatz: genes, virulence, and resistance
• Verf.angabe: Nico T. Mutters, Christian P. Bieber, Catherine Hauck, Gerald Reiner, Veronika Malek, Uwe Frank
• E-Jahr: 2016
• Jahr: 26 August 2016
• Umfang: 5 S.
• Teil: volume:86
• Teil: year:2016
• Teil: number:4
• Teil: pages:417-421
• Teil: extent:5
• Fussnoten: Gesehen am 05.12.2017
• Titel Quelle: Enthalten in: Diagnostic microbiology and infectious disease
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1983
• Jahr Quelle: 2016
• Band/Heft Quelle: 86(2016), 4, Seite 417-421
• ISSN Quelle: 1879-0070
• DOI: doi:10.1016/j.diagmicrobio.2016.08.016
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: CC398
• Sach-SW: Genotyping
• Sach-SW: Infection control
• Sach-SW: Livestock
• Sach-SW: MRSA
• Sach-SW: Pig farms
• Sach-SW: Transmission
• K10plus-PPN: 1566054885

Abstract

Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) may colonize and infect humans with close contact to pigs. We compared phenotypic and genotypic differences in resistance and virulence of LA-MRSA isolates from farms and farmers with hospital-acquired methicillin-resistant S. aureus (HA-MRSA) and assessed carriage rates. Samples from pigs (n=330), occupationally exposed personnel (n=63), the farm environment (n=134), and hospital patients (n=220) were obtained. Approximately 50% (166/330) of pigs were MRSA positive. All LA-MRSA were resistant to tetracycline, compared to only 8% of HA-MRSA (P<0.001). In contrast, HA-MRSA isolates showed significantly higher resistance rates to quinolones (81% versus 7%; P<0.001). All strains isolated from occupationally exposed personnel (61.9%; 39/63) belonged to CC398. HA-MRSA isolates were diversely distributed, with predominance of CC5 (62.7%). Human strains carried significantly more virulence genes than porcine strains, especially exotoxins (P<0.001) and immune-evasion cluster genes (P<0.001). There were significant differences in resistance patterns and recognized genotypic virulence loci between LA-MRSA and HA-MRSA.