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Verfasst von:Jiang, Huanhuan [VerfasserIn]   i
 Gebhardt, Christoffer [VerfasserIn]   i
 Schulze, Torsten [VerfasserIn]   i
 Utikal, Jochen [VerfasserIn]   i
 Umansky, Viktor [VerfasserIn]   i
Titel:Elevated chronic inflammatory factors and myeloid-derived suppressor cells indicate poor prognosis in advanced melanoma patients
Verf.angabe:Huanhuan Jiang, Christoffer Gebhardt, Ludmila Umansky, Philipp Beckhove, Torsten J. Schulze, Jochen Utikal and Viktor Umansky
E-Jahr:2015
Jahr:15 May 2015
Umfang:9 S.
Fussnoten:Gesehen am 05.12.2017
Titel Quelle:Enthalten in: International journal of cancer
Ort Quelle:Bognor Regis : Wiley-Liss, 1966
Jahr Quelle:2015
Band/Heft Quelle:136(2015), 10, Seite 2352-2360
ISSN Quelle:1097-0215
Abstract:Chronic inflammation is considered to be one of the hallmarks for tumor initiation and progression. Moreover, a long-term production and accumulation of inflammatory factors lead to a local and systemic immunosuppression associated with cancer progression. However, the correlation between inflammatory mediators, immunosuppressive cells and the clinical outcome of malignant melanoma patients was poorly investigated. In this study, we performed a complex analysis of various inflammatory factors, myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) in the peripheral blood of patients suffering from malignant melanoma of different stages. We demonstrated that levels of serum IL-1β, IFN-γ and CXCL10 were significantly increased in advanced melanoma patients. In addition, these factors were found to be associated with an increased frequency of MDSCs and Tregs as compared to age- and gender-matched healthy donors. Importantly, advanced melanoma patients with signs of progression displayed markedly elevated concentrations of IL-1β and CXCL10 as compared to patients with stable disease. Moreover, an enrichment of circulating monocytic (Mo)-MDSCs significantly correlated with a decreased progression free survival of these patients. Our data highlight a complex association between circulating inflammatory mediators, Mo-MDSCs and the clinical outcome as well as suggest that their levels in patients with advanced melanoma are of important prognostic value allowing the identification of those with high risk of disease progression.
DOI:doi:10.1002/ijc.29297
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

teilw. kostenfrei: Volltext: http://dx.doi.org/10.1002/ijc.29297
 teilw. kostenfrei: Volltext: http://onlinelibrary.wiley.com.ezproxy.medma.uni-heidelberg.de/doi/10.1002/ijc.29297/abstract
 DOI: https://doi.org/10.1002/ijc.29297
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:chronic inflammatory factors
 immunosuppression
 melanoma
 myeloid-derived suppressor cells
 regulatory T cells
K10plus-PPN:1566066549
Verknüpfungen:→ Zeitschrift

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