68Ga-PSMA-11 dynamic PET/CT imaging in primary prostate cancer

• Verfasst von: Sachpekidis, Christos [VerfasserIn]
• Verfasst von: Hadaschik, Boris [VerfasserIn]
• Verfasst von: Haberkorn, Uwe [VerfasserIn]
• Verfasst von: Dimitrakopoulou-Strauss, Antonia [VerfasserIn]
• Titel: 68Ga-PSMA-11 dynamic PET/CT imaging in primary prostate cancer
• Verf.angabe: Christos Sachpekidis, MD, Klaus Kopka, PhD, Matthias Eder, PhD, Boris A. Hadaschik, MD, Martin T. Freitag, MD, Leyun Pan, PhD, Uwe Haberkorn, MD, Antonia Dimitrakopoulou-Strauss, MD
• E-Jahr: 2016
• Jahr: July 3, 2016
• Umfang: 7 S.
• Fussnoten: Im Titel ist 68 hochgestellt ; Gesehen am 06.12.2017
• Titel Quelle: Enthalten in: Clinical nuclear medicine
• Ort Quelle: Philadelphia, Pa. : Lippincott Williams & Wilkins, 1976
• Jahr Quelle: 2016
• Band/Heft Quelle: 41(2016), 11, Seite E473-E479
• ISSN Quelle: 1536-0229
• DOI: doi:10.1097/RLU.0000000000001349
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1566087392

Abstract

The aim of our study is to assess the pharmacokinetics and biodistribution of 68Ga-PSMA-11 in patients suffering from primary prostate cancer (PC) by means of dynamic and whole-body PET/CT. Twenty-four patients with primary, previously untreated PC were enrolled in the study. All patients underwent dynamic PET/CT (dPET/CT) scanning of the pelvis and whole-body PET/CT studies with 68Ga-PSMA-11. The evaluation of dPET/CT studies was based on qualitative evaluation, SUV calculation, and quantitative analysis based on two-tissue compartment modeling and a noncompartmental approach leading to the extraction of fractal dimension (FD). A total of 23/24 patients (95.8%) were 68Ga-PSMA-11 positive. In 9/24 patients (37.5%), metastatic lesions were detected. PC-associated lesions demonstrated the following mean values: SUVaverage = 14.3, SUVmax = 23.4, K1 = 0.24 (1/min), k3 = 0.34 (1/min), influx = 0.15 (1/min), and FD = 1.27. The parameters SUVaverage, SUVmax, k3, influx, and FD derived from PC-associated lesions were significantly higher than respective values derived from reference prostate tissue. Time-activity curves derived from PC-associated lesions revealed an increasing 68Ga-PSMA-11 accumulation during dynamic PET acquisition. Correlation analysis revealed a moderate but significant correlation between PSA levels and SUVaverage (r = 0.60) and SUVmax (r = 0.57), and a weak but significant correlation between Gleason score and SUVaverage (r = 0.33) and SUVmax (r = 0.28). 68Ga-PSMA-11 PET/CT confirmed its capacity in detecting primary PC with a detection rate of 95.8%. Dynamic PET/CT studies of the pelvis revealed an increase in tracer uptake in PC-associated lesions during the 60 minutes of dynamic PET acquisition, a finding with potential applications in anti-PSMA approaches.