Multiscale modeling of virus replication and spread

• Verfasst von: Kumberger, Peter [VerfasserIn]
• Verfasst von: Frey, Felix [VerfasserIn]
• Verfasst von: Schwarz, Ulrich S. [VerfasserIn]
• Verfasst von: Graw, Frederik [VerfasserIn]
• Titel: Multiscale modeling of virus replication and spread
• Verf.angabe: Peter Kumberger, Felix Frey, Ulrich S. Schwarz and Frederik Graw
• Umfang: 15 S.
• Fussnoten: Gesehen am 07.12.2017
• Titel Quelle: Enthalten in: Vereinigung der Europäischen Biochemischen Gesellschaften: FEBS letters
• Jahr Quelle: 2016
• Band/Heft Quelle: 590(2016), 13, S. 1972-1986
• ISSN Quelle: 1873-3468
• DOI: doi:10.1002/1873-3468.12095
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1566139724

Abstract

Replication and spread of human viruses is based on the simultaneous exploitation of many different host functions, bridging multiple scales in space and time. Mathematical modeling is essential to obtain a systems-level understanding of how human viruses manage to proceed through their life cycles. Here, we review corresponding advances for viral systems of large medical relevance, such as human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV). We will outline how the combination of mathematical models and experimental data has advanced our quantitative knowledge about various processes of these pathogens, and how novel quantitative approaches promise to fill remaining gaps.