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Status: Bibliographieeintrag

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Verfasst von:Mai, Elias K. [VerfasserIn]   i
 Kloth, Jost [VerfasserIn]   i
 Merz, Maximilian [VerfasserIn]   i
 Shah, Sofia [VerfasserIn]   i
 Hillengaß, Michaela [VerfasserIn]   i
 Wagner, Barbara [VerfasserIn]   i
 Hose, Dirk [VerfasserIn]   i
 Raab, Marc-Steffen [VerfasserIn]   i
 Jauch, Anna [VerfasserIn]   i
 Goldschmidt, Hartmut [VerfasserIn]   i
 Weber, Marc-André [VerfasserIn]   i
 Hillengaß, Jens [VerfasserIn]   i
Titel:Association between magnetic resonance imaging patterns and baseline disease features in multiple myeloma
Titelzusatz:analyzing surrogates of tumour mass and biology
Verf.angabe:Elias K. Mai, Thomas Hielscher, Jost K. Kloth, Maximilian Merz, Sofia Shah, Michaela Hillengass, Barbara Wagner, Dirk Hose, M. S. Raab, Anna Jauch, Stefan Delorme, Hartmut Goldschmidt, Marc-André Weber, Jens Hillengass
E-Jahr:2016
Jahr:15 January 2016
Umfang:10 S.
Fussnoten:Gesehen am 11.12.2017
Titel Quelle:Enthalten in: European radiology
Ort Quelle:Berlin : Springer, 1991
Jahr Quelle:2016
Band/Heft Quelle:26(2016), 11, Seite 3939-3948
ISSN Quelle:1432-1084
 1613-3757
Abstract:OBJECTIVE: To assess associations between bone marrow infiltration patterns and localization in magnetic resonance imaging (MRI) and baseline clinical/prognostic parameters in multiple myeloma (MM). METHODS: We compared baseline MM parameters, MRI patterns and localization of focal lesions to the mineralized bone in 206 newly diagnosed MM patients. RESULTS: A high tumour mass (represented by International Staging System stage III) was significantly associated with severe diffuse infiltration (p = 0.015) and a higher number of focal lesions (p = 0.006). Elevated creatinine (p = 0.003), anaemia (p < 0.001) and high LDH (p = 0.001) correlated with severe diffuse infiltration. A salt and pepper diffuse pattern had a favourable prognosis. A higher degree of destruction of mineralized bone (assessed by X-ray or computed tomography) was associated with an increasing number of focal lesions on MRI (p < 0.001). Adverse cytogenetics (del17p/gain1q21/t(4;14)) were associated with diffuse infiltration (p = 0.008). The presence of intraosseous focal lesions exceeding the mineralized bone had a borderline significant impact on prognosis. CONCLUSIONS: Diffuse bone marrow infiltration on MRI correlates with adverse cytogenetics, lowered haemoglobin values and high tumour burden in newly diagnosed MM whereas an increasing number of focal lesions correlates with a higher degree of bone destruction. Focal lesions exceeding the cortical bone did not adversely affect the prognosis. KEY POINTS: • Diffuse MRI correlates with adverse cytogenetics, lowered haemoglobin and high tumour burden. • Higher numbers of MRI focal lesions correlate with increasing degree of bone destruction. • Focal lesions exceeding the cortical bone borderline significantly influence survival. • Moderate/severe diffuse infiltration and more than 23 focal lesions adversely affect survival.
DOI:doi:10.1007/s00330-015-4195-0
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

DOI: https://doi.org/10.1007/s00330-015-4195-0
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Aged
 Humans
 Male
 Retrospective Studies
 Tomography, X-Ray Computed
 Bone marrow
 Bone Marrow
 Bone Marrow Neoplasms
 Magnetic resonance imaging
 Magnetic Resonance Imaging
 Multiple myeloma
 Multiple Myeloma
 Neoplasm Invasiveness
 Neoplasm Staging
 Plasma cells
 Prognosis
K10plus-PPN:1566250226
Verknüpfungen:→ Zeitschrift

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