Association between magnetic resonance imaging patterns and baseline disease features in multiple myeloma

• Verfasst von: Mai, Elias K. [VerfasserIn]
• Verfasst von: Kloth, Jost [VerfasserIn]
• Verfasst von: Merz, Maximilian [VerfasserIn]
• Verfasst von: Shah, Sofia [VerfasserIn]
• Verfasst von: Hillengaß, Michaela [VerfasserIn]
• Verfasst von: Wagner, Barbara [VerfasserIn]
• Verfasst von: Hose, Dirk [VerfasserIn]
• Verfasst von: Raab, Marc-Steffen [VerfasserIn]
• Verfasst von: Jauch, Anna [VerfasserIn]
• Verfasst von: Goldschmidt, Hartmut [VerfasserIn]
• Verfasst von: Weber, Marc-André [VerfasserIn]
• Verfasst von: Hillengaß, Jens [VerfasserIn]
• Titel: Association between magnetic resonance imaging patterns and baseline disease features in multiple myeloma
• Titelzusatz: analyzing surrogates of tumour mass and biology
• Verf.angabe: Elias K. Mai, Thomas Hielscher, Jost K. Kloth, Maximilian Merz, Sofia Shah, Michaela Hillengass, Barbara Wagner, Dirk Hose, M. S. Raab, Anna Jauch, Stefan Delorme, Hartmut Goldschmidt, Marc-André Weber, Jens Hillengass
• E-Jahr: 2016
• Jahr: 15 January 2016
• Umfang: 10 S.
• Fussnoten: Gesehen am 11.12.2017
• Titel Quelle: Enthalten in: European radiology
• Ort Quelle: Berlin : Springer, 1991
• Jahr Quelle: 2016
• Band/Heft Quelle: 26(2016), 11, Seite 3939-3948
• ISSN Quelle: 1432-1084
• ISSN Quelle: 1613-3757
• DOI: doi:10.1007/s00330-015-4195-0
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Aged
• Sach-SW: Humans
• Sach-SW: Male
• Sach-SW: Retrospective Studies
• Sach-SW: Tomography, X-Ray Computed
• Sach-SW: Bone marrow
• Sach-SW: Bone Marrow
• Sach-SW: Bone Marrow Neoplasms
• Sach-SW: Magnetic resonance imaging
• Sach-SW: Magnetic Resonance Imaging
• Sach-SW: Multiple myeloma
• Sach-SW: Multiple Myeloma
• Sach-SW: Neoplasm Invasiveness
• Sach-SW: Neoplasm Staging
• Sach-SW: Plasma cells
• Sach-SW: Prognosis
• K10plus-PPN: 1566250226

Abstract

OBJECTIVE: To assess associations between bone marrow infiltration patterns and localization in magnetic resonance imaging (MRI) and baseline clinical/prognostic parameters in multiple myeloma (MM). METHODS: We compared baseline MM parameters, MRI patterns and localization of focal lesions to the mineralized bone in 206 newly diagnosed MM patients. RESULTS: A high tumour mass (represented by International Staging System stage III) was significantly associated with severe diffuse infiltration (p = 0.015) and a higher number of focal lesions (p = 0.006). Elevated creatinine (p = 0.003), anaemia (p < 0.001) and high LDH (p = 0.001) correlated with severe diffuse infiltration. A salt and pepper diffuse pattern had a favourable prognosis. A higher degree of destruction of mineralized bone (assessed by X-ray or computed tomography) was associated with an increasing number of focal lesions on MRI (p < 0.001). Adverse cytogenetics (del17p/gain1q21/t(4;14)) were associated with diffuse infiltration (p = 0.008). The presence of intraosseous focal lesions exceeding the mineralized bone had a borderline significant impact on prognosis. CONCLUSIONS: Diffuse bone marrow infiltration on MRI correlates with adverse cytogenetics, lowered haemoglobin values and high tumour burden in newly diagnosed MM whereas an increasing number of focal lesions correlates with a higher degree of bone destruction. Focal lesions exceeding the cortical bone did not adversely affect the prognosis. KEY POINTS: • Diffuse MRI correlates with adverse cytogenetics, lowered haemoglobin and high tumour burden. • Higher numbers of MRI focal lesions correlate with increasing degree of bone destruction. • Focal lesions exceeding the cortical bone borderline significantly influence survival. • Moderate/severe diffuse infiltration and more than 23 focal lesions adversely affect survival.