| Online-Ressource |
Verfasst von: | Mai, Elias K. [VerfasserIn]  |
| Kloth, Jost [VerfasserIn]  |
| Merz, Maximilian [VerfasserIn]  |
| Shah, Sofia [VerfasserIn]  |
| Hillengaß, Michaela [VerfasserIn]  |
| Wagner, Barbara [VerfasserIn]  |
| Hose, Dirk [VerfasserIn]  |
| Raab, Marc-Steffen [VerfasserIn]  |
| Jauch, Anna [VerfasserIn]  |
| Goldschmidt, Hartmut [VerfasserIn]  |
| Weber, Marc-André [VerfasserIn]  |
| Hillengaß, Jens [VerfasserIn]  |
Titel: | Association between magnetic resonance imaging patterns and baseline disease features in multiple myeloma |
Titelzusatz: | analyzing surrogates of tumour mass and biology |
Verf.angabe: | Elias K. Mai, Thomas Hielscher, Jost K. Kloth, Maximilian Merz, Sofia Shah, Michaela Hillengass, Barbara Wagner, Dirk Hose, M. S. Raab, Anna Jauch, Stefan Delorme, Hartmut Goldschmidt, Marc-André Weber, Jens Hillengass |
E-Jahr: | 2016 |
Jahr: | 15 January 2016 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 11.12.2017 |
Titel Quelle: | Enthalten in: European radiology |
Ort Quelle: | Berlin : Springer, 1991 |
Jahr Quelle: | 2016 |
Band/Heft Quelle: | 26(2016), 11, Seite 3939-3948 |
ISSN Quelle: | 1432-1084 |
| 1613-3757 |
Abstract: | OBJECTIVE: To assess associations between bone marrow infiltration patterns and localization in magnetic resonance imaging (MRI) and baseline clinical/prognostic parameters in multiple myeloma (MM). METHODS: We compared baseline MM parameters, MRI patterns and localization of focal lesions to the mineralized bone in 206 newly diagnosed MM patients. RESULTS: A high tumour mass (represented by International Staging System stage III) was significantly associated with severe diffuse infiltration (p = 0.015) and a higher number of focal lesions (p = 0.006). Elevated creatinine (p = 0.003), anaemia (p < 0.001) and high LDH (p = 0.001) correlated with severe diffuse infiltration. A salt and pepper diffuse pattern had a favourable prognosis. A higher degree of destruction of mineralized bone (assessed by X-ray or computed tomography) was associated with an increasing number of focal lesions on MRI (p < 0.001). Adverse cytogenetics (del17p/gain1q21/t(4;14)) were associated with diffuse infiltration (p = 0.008). The presence of intraosseous focal lesions exceeding the mineralized bone had a borderline significant impact on prognosis. CONCLUSIONS: Diffuse bone marrow infiltration on MRI correlates with adverse cytogenetics, lowered haemoglobin values and high tumour burden in newly diagnosed MM whereas an increasing number of focal lesions correlates with a higher degree of bone destruction. Focal lesions exceeding the cortical bone did not adversely affect the prognosis. KEY POINTS: • Diffuse MRI correlates with adverse cytogenetics, lowered haemoglobin and high tumour burden. • Higher numbers of MRI focal lesions correlate with increasing degree of bone destruction. • Focal lesions exceeding the cortical bone borderline significantly influence survival. • Moderate/severe diffuse infiltration and more than 23 focal lesions adversely affect survival. |
DOI: | doi:10.1007/s00330-015-4195-0 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
DOI: https://doi.org/10.1007/s00330-015-4195-0 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Aged |
| Humans |
| Male |
| Retrospective Studies |
| Tomography, X-Ray Computed |
| Bone marrow |
| Bone Marrow |
| Bone Marrow Neoplasms |
| Magnetic resonance imaging |
| Magnetic Resonance Imaging |
| Multiple myeloma |
| Multiple Myeloma |
| Neoplasm Invasiveness |
| Neoplasm Staging |
| Plasma cells |
| Prognosis |
K10plus-PPN: | 1566250226 |
Verknüpfungen: | → Zeitschrift |
Association between magnetic resonance imaging patterns and baseline disease features in multiple myeloma / Mai, Elias K. [VerfasserIn]; 15 January 2016 (Online-Ressource)