| |  Online-Ressource |
|---|
| Verfasst von: | Hellmann, Janina K. [VerfasserIn]  |
|---|
| | Münter, Sylvia [VerfasserIn] |
|---|
| | Kudryashev, Mikhail [VerfasserIn] |
|---|
| | Heiß, Kirsten [VerfasserIn] |
|---|
| | Müller, Ann-Kristin [VerfasserIn] |
|---|
| | Matuschewski, Kai [VerfasserIn] |
|---|
| | Spatz, Joachim P. [VerfasserIn] |
|---|
| | Schwarz, Ulrich S. [VerfasserIn] |
|---|
| | Frischknecht, Friedrich [VerfasserIn] |
|---|
| Titel: | Environmental constraints guide migration of Malaria parasites during transmission |
|---|
| Verf.angabe: | Janina Kristin Hellmann, Sylvia Münter, Mikhail Kudryashev, Simon Schulz, Kirsten Heiss, Ann-Kristin Müller, Kai Matuschewski, Joachim P. Spatz, Ulrich S. Schwarz, Friedrich Frischknecht |
|---|
| E-Jahr: | 2011 |
|---|
| Jahr: | June 16, 2011 |
|---|
| Fussnoten: | Gesehen am 08.12.2017 |
|---|
| Titel Quelle: | Enthalten in: Public Library of SciencePLoS pathogens |
|---|
| Ort Quelle: | Lawrence, Kan. : PLoS, 2005 |
|---|
| Jahr Quelle: | 2011 |
|---|
| Band/Heft Quelle: | 7(2011,6) Artikel-Nummer e1002080, 12 Seiten |
|---|
| ISSN Quelle: | 1553-7374 |
|---|
| Abstract: | Author Summary Guidance of motile cells plays an important role during the life of a multi-cellular organism from early embryogenesis to the intricate interactions of immune cells during an infection. These migrations, like those of pathogens, can be directed by both chemical and physical cues. The malaria parasite needs to migrate immediately after being injected into the skin of the host by a mosquito bite. The malaria parasite forms deposited in the skin are called sporozoites. These must penetrate the dermis of the host to reach and enter a blood vessel. It is not clear if the sporozoites follow chemical cues or rely on the physical context of the environment. We show here, using in vivo imaging that sporozoites migrate along different paths in different skin environments. Introducing a novel assay for the study of cell migration in general we show that these in vivo paths can be largely recreated in vitro by placing sporozoites in a micro-patterned environment. This shows that environmental constraints are sufficient to guide sporozoite migration in the skin dermis. We further speculate that sporozoites have evolved to migrate at the fastest speed possible for efficient dispersal and show that a parasite lacking a surface protein has substantial defects in tissue dispersal and thus cannot efficiently infect the host. |
|---|
| DOI: | doi:10.1371/journal.ppat.1002080 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1371/journal.ppat.1002080 |
|---|
| | Volltext: http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1002080 |
|---|
| | DOI: https://doi.org/10.1371/journal.ppat.1002080 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Cell motility |
|---|
| | Dermis |
|---|
| | Ears |
|---|
| | Malarial parasites |
|---|
| | Parasitic diseases |
|---|
| | Pathogen motility |
|---|
| | Plasmodium |
|---|
| | Sporozoites |
|---|
| K10plus-PPN: | 1566173884 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Environmental constraints guide migration of Malaria parasites during transmission / Hellmann, Janina K. [VerfasserIn]; June 16, 2011 (Online-Ressource)
