Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Besser, Achim [VerfasserIn]  |
| Schwarz, Ulrich S. [VerfasserIn]  |
Titel: | Hysteresis in the cell response to time-dependent substrate stiffness |
Verf.angabe: | Achim Besser, University of Heidelberg, Bioquant, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany ; Ulrich S. Schwarz, University of Heidelberg, Bioquant, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany and University of Heidelberg, Institute for Theoretical Physics, Philosophenweg 19, 69120 Heidelberg, Germany |
Fussnoten: | Gesehen am 08.12.2017 |
Titel Quelle: | Enthalten in: De.arxiv.org |
Jahr Quelle: | 2010 |
Band/Heft Quelle: | (2010) Artikel-Nummer 1007.1092, 7 Seiten |
Abstract: | Mechanical cues like the rigidity of the substrate are main determinants for the decision making of adherent cells. Here we use a mechano-chemical model to predict the cellular response to varying substrate stiffness. The model equations combine the mechanics of contractile actin filament bundles with a model for the Rho-signaling pathway triggered by forces at cell-matrix contacts. A bifurcation analysis of cellular contractility as a function of substrate stiffness reveals a bistable response, thus defining a lower threshold of stiffness, below which cells are not able to build up contractile forces, and an upper threshold of stiffness, above which cells are always in a strongly contracted state. Using the full dynamical model, we predict that rate-dependent hysteresis will occur in the cellular traction forces when cells are exposed to substrates of time-dependent stiffness. |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Kostenfrei: Verlag: http://arxiv.org/abs/1007.1092 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1566176069 |
Verknüpfungen: | → Sammelwerk |
Hysteresis in the cell response to time-dependent substrate stiffness / Besser, Achim [VerfasserIn] (Online-Ressource)
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