Effect of adhesion geometry and rigidity on cellular force distributions

• Verfasst von: Bischofs-Pfeifer, Ilka [VerfasserIn]
• Verfasst von: Schmidt, Sebastian Simon [VerfasserIn]
• Verfasst von: Schwarz, Ulrich S. [VerfasserIn]
• Titel: Effect of adhesion geometry and rigidity on cellular force distributions
• Verf.angabe: Ilka B. Bischofs, Sebastian S. Schmidt, and Ulrich S. Schwarz
• Jahr: 2009
• Umfang: 4 S.
• Teil: year:2009
• Teil: extent:4
• Fussnoten: Gesehen am 08.12.2017
• Titel Quelle: Enthalten in: De.arxiv.org
• Ort Quelle: [S.l.] : Arxiv.org, 1991
• Jahr Quelle: 2009
• Band/Heft Quelle: (2009) Artikel-Nummer 0907.4114, 4 Seiten
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Condensed Matter - Soft Condensed Matter
• Sach-SW: Quantitative Biology - Cell Behavior
• K10plus-PPN: 1566182921

Abstract

The behaviour and fate of tissue cells is controlled by the rigidity and geometry of their adhesive environment, possibly through forces localized to sites of adhesion. We introduce a mechanical model that predicts cellular force distributions for cells adhering to adhesive patterns with different geometries and rigidities. For continuous adhesion along a closed contour, forces are predicted to be localized to the corners. For discrete sites of adhesion, the model predicts the forces to be mainly determined by the lateral pull of the cell contour. With increasing distance between two neighboring sites of adhesion, the adhesion force increases because cell shape results in steeper pulling directions. Softer substrates result in smaller forces. Our predictions agree well with experimental force patterns measured on pillar assays.