Impact of receptor-ligand distance on adhesion cluster stability

• Verfasst von: Erdmann, Thorsten [VerfasserIn]
• Verfasst von: Schwarz, Ulrich S. [VerfasserIn]
• Titel: Impact of receptor-ligand distance on adhesion cluster stability
• Verf.angabe: T. Erdmann and U.S. Schwarz
• E-Jahr: 2007
• Jahr: 09 March 2007
• Umfang: 15 S.
• Teil: volume:22
• Teil: year:2007
• Teil: number:2
• Teil: pages:123-137
• Teil: extent:15
• Fussnoten: Gesehen am 12.12.2017
• Titel Quelle: Enthalten in: The European physical journal / E
• Ort Quelle: Berlin : Springer, 2000
• Jahr Quelle: 2007
• Band/Heft Quelle: 22(2007), 2, Seite 123-137
• ISSN Quelle: 1292-895X
• DOI: doi:10.1140/epje/e2007-00019-8
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1566262968

Abstract

Cells in multicellular organisms adhere to the extracellular matrix through two-dimensional clusters spanning a size range from very few to thousands of adhesion bonds. For many common receptor-ligand systems, the ligands are tethered to a surface via polymeric spacers with finite binding range, thus adhesion cluster stability crucially depends on receptor-ligand distance. We introduce a one-step master equation which incorporates the effect of cooperative binding through a finite number of polymeric ligand tethers. We also derive Fokker-Planck and mean field equations as continuum limits of the master equation. Polymers are modeled either as harmonic springs or as worm-like chains. In both cases, we find bistability between bound and unbound states for intermediate values of receptor-ligand distance and calculate the corresponding switching times. For small cluster sizes, stochastic effects destabilize the clusters at large separation, as shown by a detailed analysis of the stochastic potential resulting from the Fokker-Planck equation.