Mean first passage times for bond formation for a Brownian particle in linear shear flow above a wall

• Verfasst von: Korn, Christian B. [VerfasserIn]
• Verfasst von: Schwarz, Ulrich S. [VerfasserIn]
• Titel: Mean first passage times for bond formation for a Brownian particle in linear shear flow above a wall
• Verf.angabe: C.B. Korn, University of Heidelberg, Im Neuenheimer Feld 293, D-69120, Germany and Max Planck Institute of Colloids and Interfaces, D-14424 Potsdam, Germany; U.S. Schwarz, University of Heidelberg, Im Neuenheimer Feld 293, D-69120, Germany
• E-Jahr: 2007
• Jahr: 5 March 2007
• Umfang: 17 S.
• Teil: volume:126
• Teil: year:2007
• Teil: number:9
• Teil: extent:17
• Fussnoten: Gesehen am 12.12.2017
• Titel Quelle: Enthalten in: The journal of chemical physics
• Ort Quelle: Melville, NY : American Institute of Physics, 1933
• Jahr Quelle: 2007
• Band/Heft Quelle: 126(2007,9) Artikelnummer 095103, 17 Seiten
• ISSN Quelle: 1089-7690
• DOI: doi:10.1063/1.2464080
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1566265142

Abstract

Motivated by cell adhesion in hydrodynamic flow, here the authors study bond formation between a spherical Brownian particle in linear shear flow carrying receptors for ligands covering the boundary wall. They derive the appropriate Langevin equation which includes multiplicative noise due to position-dependent mobility functions resulting from the Stokes equation. They present a numerical scheme which allows to simulate it with high accuracy for all model parameters, including shear rate and three parameters describing receptor geometry (distance, size, and height of the receptor patches). In the case of homogeneous coating, the mean first passage time problem can be solved exactly. In the case of position-resolved receptor-ligand binding, they identify different scaling regimes and discuss their biological relevance.