Efficiency of initiating cell adhesion in hydrodynamic flow

• Verfasst von: Korn, Christian B. [VerfasserIn]
• Verfasst von: Schwarz, Ulrich S. [VerfasserIn]
• Titel: Efficiency of initiating cell adhesion in hydrodynamic flow
• Verf.angabe: C. Korn and U.S. Schwarz
• Jahr: 2006
• Umfang: 4 S.
• Teil: year:2006
• Teil: extent:4
• Fussnoten: Gesehen am 12.12.2017
• Titel Quelle: Enthalten in: De.arxiv.org
• Ort Quelle: [S.l.] : Arxiv.org, 1991
• Jahr Quelle: 2006
• Band/Heft Quelle: (2006) Artikel-Nummer 0609093, 4 Seiten
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Condensed Matter - Soft Condensed Matter
• Sach-SW: Condensed Matter - Materials Science
• Sach-SW: Quantitative Biology - Cell Behavior
• K10plus-PPN: 156626653X

Abstract

We theoretically investigate the efficiency of initial binding between a receptor-coated sphere and a ligand-coated wall in linear shear flow. The mean first passage time for binding decreases monotonically with increasing shear rate. Above a saturation threshold of the order of a few 100 receptor patches, the binding efficiency is enhanced only weakly by increasing their number and size, but strongly by increasing their height. This explains why white blood cells in the blood flow adhere through receptor patches localized to the tips of microvilli, and why malaria-infected red blood cells form elevated receptor patches (knobs).