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Verfasst von:Tsagogiorgas, Charalambos [VerfasserIn]   i
 Heesch, Elisabeth Sabine [VerfasserIn]   i
 Krebs, Jörg [VerfasserIn]   i
 Beck, Grietje [VerfasserIn]   i
 Yard, Benito A. [VerfasserIn]   i
Titel:Evaluation of pharmacokinetic properties and anaesthetic effects of propofol in a new perfluorohexyloctane (F6H8) emulsion in rats
Titelzusatz:a comparative study
Verf.angabe:Charalambos Tsagogiorgas, Sonja Theisinger, Elisabeth Heesch, Jörg Krebs, René Holm, Grietje Beck, Benito Yard
E-Jahr:2015
Jahr:30 May 2015
Umfang:8 S.
Fussnoten:Gesehen am 13.12.2017
Titel Quelle:Enthalten in: International journal of pharmaceutics
Ort Quelle:New York, NY [u.a.] : Elsevier, 1978
Jahr Quelle:2015
Band/Heft Quelle:486(2015), 1/2, Seite 69-76
ISSN Quelle:1873-3476
Abstract:Propofol (2,6-diisopropylphenol) is a safe and widely used anaesthetic, but due to low water solubility and high lipophilicity a difficult compound to formulate. The solubility of propofol in the semifluorinated alkane perfluorohexyloctane (F6H8) is very high (>300mg/ml). In the present work we investigate if a F6H8-based emulsion could be used as a new intravenous drug delivery system for propofol from a pharmacokinetic, pharmacodynamic and safety point of view. The pharmacokinetic parameters were evaluated after an intravenous bolus injection of either Disoprivan® or a F6H8-based propofol emulsion in Wistar rats. The onset and end of sedation after multiple dosings (5, 10 and 15mg/kg bw) were examined. Clinical chemistry and histology were assessed. No significant difference was found for any of the pharmacokinetic parameters. No differences in the onset nor the end of sedation in the tested dosages could be detected. Histology scores revealed no differences. A slightly increased alanine aminotransferase (ALT) was measured after multiple application of the F6H8-propofol emulsion. In conclusion, the F6H8-propofol emulsion showed no significant different pharmacokinetics and sedation properties, compared to a commercial soy-based propofol emulsion. Further, no toxic effects could be detected on the F6H8 emulsion indicating it was a safe excipient in rats.
DOI:doi:10.1016/j.ijpharm.2015.03.037
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.ijpharm.2015.03.037
 Volltext: http://www.sciencedirect.com/science/article/pii/S0378517315002537
 DOI: https://doi.org/10.1016/j.ijpharm.2015.03.037
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Drug delivery
 Emulsion
 F6H8
 Perfluorocarbon
 Propofol
 Semifluorinated alkane
K10plus-PPN:1566351138
Verknüpfungen:→ Zeitschrift

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