| |  Online-Ressource |
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| Verfasst von: | Radtke, Jan Philipp [VerfasserIn]  |
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| | Schwab, Constantin [VerfasserIn] |
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| | Wolf, Maya Barbara [VerfasserIn] |
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| | Kesch, Claudia [VerfasserIn] |
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| | Popeneciu, Valentin [VerfasserIn] |
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| | Hüttenbrink, Clemens [VerfasserIn] |
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| | Gasch, Claudia [VerfasserIn] |
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| | Klein, Tilman [VerfasserIn] |
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| | Bonekamp, David [VerfasserIn] |
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| | Duensing, Stefan [VerfasserIn] |
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| | Roth, Wilfried [VerfasserIn] |
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| | Schüler, Svenja [VerfasserIn] |
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| | Stock, Christian [VerfasserIn] |
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| | Schlemmer, Heinz-Peter [VerfasserIn] |
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| | Röthke, Matthias C. [VerfasserIn] |
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| | Hohenfellner, Markus [VerfasserIn] |
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| | Hadaschik, Boris [VerfasserIn] |
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| Titel: | Multiparametric magnetic resonance imaging (MRI) and MRI-transrectal ultrasound fusion biopsy for index tumor detection |
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| Titelzusatz: | correlation with radical prostatectomy specimen |
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| Verf.angabe: | Jan P. Radtke, Constantin Schwab, Maya B. Wolf, Martin T. Freitag, Celine D. Alt, Claudia Kesch, Ionel V. Popeneciu, Clemens Huettenbrink, Claudia Gasch, Tilman Klein, David Bonekamp, Stefan Duensing, Wilfried Roth, Svenja Schueler, Christian Stock, Heinz-Peter Schlemmer, Matthias Roethke, Markus Hohenfellner, Boris A. Hadaschik |
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| Jahr: | 2016 |
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| Jahr des Originals: | 2015 |
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| Umfang: | 8 S. |
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| Teil: | volume:70 |
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| | year:2016 |
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| | number:5 |
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| | pages:846-853 |
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| | extent:8 |
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| Fussnoten: | Published online: December 29, 2015 ; Gesehen am 13.12.2017 |
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| Titel Quelle: | Enthalten in: European urology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1976 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 70(2016), 5, Seite 846-853 |
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| ISSN Quelle: | 1873-7560 |
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| | 1421-993X |
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| Abstract: | Multiparametric magnetic resonance imaging (mpMRI) and MRI fusion targeted biopsy (FTB) detect significant prostate cancer (sPCa) more accurately than conventional biopsies alone. To evaluate the detection accuracy of mpMRI and FTB on radical prostatectomy (RP) specimen. From a cohort of 755 men who underwent transperineal MRI and transrectal ultrasound fusion biopsy under general anesthesia between 2012 and 2014, we retrospectively analyzed 120 consecutive patients who had subsequent RP. All received saturation biopsy (SB) in addition to FTB of lesions with Prostate Imaging Reporting and Data System (PI-RADS) score ≥2. The index lesion was defined as the lesion with extraprostatic extension, the highest Gleason score (GS), or the largest tumor volume (TV) if GS were the same, in order of priority. GS 3+3 and TV ≥1.3ml or GS ≥3+4 and TV ≥0.55ml were considered sPCa. We assessed the detection accuracy by mpMRI and different biopsy approaches and analyzed lesion agreement between mpMRI and RP specimen. Overall, 120 index and 71 nonindex lesions were detected. Overall, 107 (89%) index and 51 (72%) nonindex lesions harbored sPCa. MpMRI detected 110 of 120 (92%) index lesions, FTB (two cores per lesion) alone diagnosed 96 of 120 (80%) index lesions, and SB alone diagnosed 110 of 120 (92%) index lesions. Combined SB and FTB detected 115 of 120 (96%) index foci. FTB performed significantly less accurately compared with mpMRI (p=0.02) and the combination for index lesion detection (p=0.002). Combined FTB and SB detected 97% of all sPCa lesions and was superior to mpMRI (85%), FTB (79%), and SB (88%) alone (p<0.001 each). Spearman's rank correlation coefficient for index lesion agreement between mpMRI and RP was 0.87 (p<0.001). Limitations included the retrospective design, multiple operators, and nonblinding of radiologists. MpMRI identified 92% of index lesions compared with RP histopathology. The combination of FTB and SB was superior to both approaches alone, reliably detecting 97% of sPCa lesions. Multiparametric magnetic resonance imaging detects the index lesion accurately in 9 of 10 patients; however, the combined biopsy approach, while missing less significant cancer, comes at the cost of detecting more insignificant cancer. |
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| DOI: | doi:10.1016/j.eururo.2015.12.052 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: http://dx.doi.org/10.1016/j.eururo.2015.12.052 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0302283816000105 |
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| | DOI: https://doi.org/10.1016/j.eururo.2015.12.052 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Bibliogr. Hinweis: | Abgeleitet: Hadaschik, Boris, 1974 - : Reply to Stephen B. Williams and John F. Ward's letter to the editor re |
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| Sach-SW: | Biopsy |
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| | Magnetic resonance imaging |
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| | Cancer volume |
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| | Image fusion |
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| | Index tumor |
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| | Predictive values |
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| | Prostate cancer |
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| | Radical prostatectomy |
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| | Ultrasound |
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| K10plus-PPN: | 156635157X |
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| Verknüpfungen: | → Zeitschrift |
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Multiparametric magnetic resonance imaging (MRI) and MRI-transrectal ultrasound fusion biopsy for index tumor detection / Radtke, Jan Philipp [VerfasserIn]; 2016 (Online-Ressource)
