Bistability of cell-matrix adhesions resulting from non-linear receptor-ligand dynamics

• Verfasst von: Erdmann, Thorsten [VerfasserIn]
• Verfasst von: Schwarz, Ulrich S. [VerfasserIn]
• Titel: Bistability of cell-matrix adhesions resulting from non-linear receptor-ligand dynamics
• Verf.angabe: T. Erdmann and U.S. Schwarz
• Jahr: 2006
• Umfang: 3 S.
• Teil: year:2006
• Teil: extent:3
• Fussnoten: Gesehen am 15.12.2017
• Titel Quelle: Enthalten in: De.arxiv.org
• Ort Quelle: [S.l.] : Arxiv.org, 1991
• Jahr Quelle: 2006
• Band/Heft Quelle: (2006) Artikel-Nummer 0608007, 3 Seiten
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Quantitative Biology - Subcellular Processes
• Sach-SW: Quantitative Biology - Biomolecules
• K10plus-PPN: 1566413621

Abstract

Bistability is a major mechanism for cellular decision making and usually results from positive feedback in biochemical control systems. Here we show theoretically that bistability between unbound and bound states of adhesion clusters results from positive feedback mediated by structural rather than biochemical processes, namely by receptor-ligand dissociation and association dynamics which depend non-linearly on mechanical force and receptor-ligand separation. For small cell-matrix adhesions, we find rapid switching between unbound and bound states, which in the initial stages of adhesion allows the cell to explore its environment through many transient adhesions.