Late outcomes after acute pulmonary embolism

• Verfasst von: Konstantinides, Stavros [VerfasserIn]
• Verfasst von: Grünig, Ekkehard [VerfasserIn]
• Titel: Late outcomes after acute pulmonary embolism
• Titelzusatz: rationale and design of FOCUS, a prospective observational multicenter cohort study
• Verf.angabe: Stavros V. Konstantinides, Stefano Barco, Stephan Rosenkranz, Mareike Lankeit, Matthias Held, Felix Gerhardt, Leonard Bruch, Ralf Ewert, Martin Faehling, Julia Freise, Hossein-Ardeschir Ghofrani, Ekkehard Grünig, Michael Halank, Nadine Heydenreich, Marius M. Hoeper, Hanno H. Leuchte, Eckhard Mayer, F. Joachim Meyer, Claus Neurohr, Christian Opitz, Antonio Pinto, Hans-Jürgen Seyfarth, Rolf Wachter, Bianca Zäpf, Heinrike Wilkens, Harald Binder, Philipp S. Wild
• E-Jahr: 2016
• Jahr: 30 August 2016
• Umfang: 10 S.
• Fussnoten: Gesehen am 18.12.2017
• Titel Quelle: Enthalten in: Journal of thrombosis and thrombolysis
• Ort Quelle: Dordrecht [u.a.] : Springer Science + Business Media B.V, 1994
• Jahr Quelle: 2016
• Band/Heft Quelle: 42(2016), 4, Seite 600-609
• ISSN Quelle: 1573-742X
• DOI: doi:10.1007/s11239-016-1415-7
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Female
• Sach-SW: Humans
• Sach-SW: Male
• Sach-SW: Prospective Studies
• Sach-SW: Disease-Free Survival
• Sach-SW: Quality of life
• Sach-SW: Acute Disease
• Sach-SW: Aftercare
• Sach-SW: Chronic thromboembolic pulmonary hypertension
• Sach-SW: Cohort study
• Sach-SW: Follow-up
• Sach-SW: Functional impairment
• Sach-SW: Pulmonary embolism
• Sach-SW: Pulmonary Embolism
• Sach-SW: Survival Rate
• K10plus-PPN: 1566507952

Abstract

Acute pulmonary embolism (PE) is a frequent cause of death and serious disability. The risk of PE-associated mortality and morbidity extends far beyond the acute phase of the disease. In earlier follow-up studies, as many as 30 % of the patients died during a follow-up period of up to 3 years, and up to 50 % of patients continued to complain of dyspnea and/or poor physical performance 6 months to 3 years after the index event. The most feared 'late sequela' of PE is chronic thromboembolic pulmonary hypertension (CTEPH), the true incidence of which remains obscure due to the large margin of error in the rates reported by mostly small, single-center studies. Moreover, the functional and hemodynamic changes corresponding to early, possibly reversible stages of CTEPH, have not been systematically investigated. The ongoing Follow-Up after acute pulmonary embolism (FOCUS) study will prospectively enroll and systematically follow, over a 2-year period and with a standardized comprehensive program of clinical, echocardiographic, functional and laboratory testing, a large multicenter prospective cohort of 1000 unselected patients (all-comers) with acute symptomatic PE. FOCUS will possess adequate power to provide answers to relevant remaining questions regarding the patients' long-term morbidity and mortality, and the temporal pattern of post-PE abnormalities. It will hopefully provide evidence for future guideline recommendations regarding the selection of patients for long-term follow-up after PE, the modalities which this follow-up should include, and the findings that should be interpreted as indicating progressive functional and hemodynamic post-PE impairment, or the development of CTEPH.