Renal transplantation in HIV-positive renal transplant recipients

• Verfasst von: Haas, Jenny [VerfasserIn]
• Verfasst von: Singer, Thomas [VerfasserIn]
• Verfasst von: Nowak, Kai [VerfasserIn]
• Verfasst von: Göttmann, Uwe [VerfasserIn]
• Verfasst von: Schnülle, Peter [VerfasserIn]
• Verfasst von: Krüger, Bernd [VerfasserIn]
• Verfasst von: Krämer, Bernhard [VerfasserIn]
• Verfasst von: Benck, Urs Tobias [VerfasserIn]
• Titel: Renal transplantation in HIV-positive renal transplant recipients
• Titelzusatz: experience at the Mannheim University Hospital
• Verf.angabe: J. Haas, T. Singer, K. Nowak, J. Brust, U. Göttmann, P. Schnülle, B. Krüger, B.K. Krämer, U. Benck
• E-Jahr: 2015
• Jahr: November 2015
• Umfang: 4 S.
• Fussnoten: Gesehen am 20.12.2017
• Titel Quelle: Enthalten in: Transplantation proceedings
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1997
• Jahr Quelle: 2015
• Band/Heft Quelle: 47(2015), 9, Seite 2791-2794
• ISSN Quelle: 1873-2623
• DOI: doi:10.1016/j.transproceed.2015.09.064
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1566579120

Abstract

Renal transplantation in HIV-positive patients with end-stage renal disease has in recent years become a successful treatment option. We report two patients who underwent renal transplantation using a combination of basiliximab, calcineurin inhibitors, mycophenolate mofetil (MMF), and steroids with a “non-interacting” antiretroviral combination therapy consisting of stavudine or abacavir, lamivudine, and nevirapine. We observed no acute rejection but a BK polyomavirus infection in both patients. In conclusion, a quadruple immunosuppression with an interleukin 2 receptor antagonist, a calcineurin inhibitor, MMF, and steroids appears to be advisable to prevent high rates of acute rejection, but if possible thereafter immunosuppression should be tapered rapidly (eg, MMF stop, prednisolone dose 5 mg/d). The selection of antiretroviral agents should avoid compounds that interact severely with the immunosuppression used.