Rituximab induces phenotypical and functional changes of NK cells in a non-malignant experimental setting

• Verfasst von: Merkt, Wolfgang [VerfasserIn]
• Verfasst von: Lorenz, Hanns-Martin [VerfasserIn]
• Verfasst von: Watzl, Carsten [VerfasserIn]
• Titel: Rituximab induces phenotypical and functional changes of NK cells in a non-malignant experimental setting
• Verf.angabe: Wolfgang Merkt, Hanns-Martin Lorenz, Carsten Watzl
• Fussnoten: Gesehen am 21.12.2017
• Titel Quelle: Enthalten in: Arthritis Research & Therapy
• Jahr Quelle: 2016
• Band/Heft Quelle: 18(2016) Artikel-Nummer 206, 11 Seiten
• ISSN Quelle: 1465-9913
• ISSN Quelle: 1478-6362
• DOI: doi:10.1186/s13075-016-1101-3
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1566638739

Abstract

Rituximab has broad and increasing application in rheumatic diseases. It is known from lymphoma studies that natural killer (NK) cells can lyse rituximab-coated transformed B cells. However, the role of NK cells in mediating rituximab-induced depletion of non-malignant B cells is unknown. The purpose of this study was to provide fundamental data on rituximab-mediated effects on NK cells in PBMCs without tumor cells, in order to simulate effects that could be relevant in patients with rheumatic disease.