GOLM1 modulates EGFR/RTK cell-surface recycling to drive hepatocellular carcinoma metastasis

• Verfasst von: Ye, Qinghai [VerfasserIn]
• Verfasst von: Rössler, Stephanie [VerfasserIn]
• Titel: GOLM1 modulates EGFR/RTK cell-surface recycling to drive hepatocellular carcinoma metastasis
• Verf.angabe: Qing-Hai Ye, Wen-Wei Zhu, Ju-Bo Zhang, Yi Qin, Ming Lu, Guo-Ling Lin, Lei Guo, Bo Zhang, Zhen-Hai Lin, Stephanie Roessler, Marshonna Forgues, Hu-Liang Jia, Lu Lu, Xiao-Fei Zhang, Bao-Feng Lian, Lu Xie, Qiong-Zhu Dong, Zhao-You Tang, Xin Wei Wang, Lun-Xiu Qin
• E-Jahr: 2016
• Jahr: 25 August 2016
• Umfang: 15 S.
• Fussnoten: Gesehen am 22.12.2017
• Titel Quelle: Enthalten in: Cancer cell
• Ort Quelle: Cambridge, Mass. : Cell Press, 2002
• Jahr Quelle: 2016
• Band/Heft Quelle: 30(2016), 3, Seite 444-458
• ISSN Quelle: 1878-3686
• DOI: doi:10.1016/j.ccell.2016.07.017
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 156674654X

Abstract

Summary The mechanism of cancer metastasis remains poorly understood. Using gene profiling of hepatocellular carcinoma (HCC) tissues, we have identified GOLM1 as a leading gene relating to HCC metastasis. GOLM1 expression is correlated with early recurrence, metastasis, and poor survival of HCC patients. Both gain- and loss-of-function studies determine that GOLM1 acts as a key oncogene by promoting HCC growth and metastasis. It selectively interacts with epidermal growth factor receptor (EGFR) and serves as a specific cargo adaptor to assist EGFR/RTK anchoring on the trans-Golgi network (TGN) and recycling back to the plasma membrane, leading to prolonged activation of the downstream kinases. These findings reveal the functional role of GOLM1, a Golgi-related protein, in EGFR/RTK recycling and metastatic progression of HCC.