Status: Bibliographieeintrag
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| Verfasst von: | Emmert, Steffen [VerfasserIn]  |
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| | Hänßle, Holger [VerfasserIn] |
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| Titel: | Tumor-preferential induction of immune responses and epidermal cell death in actinic keratoses by ingenol mebutate |
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| Verf.angabe: | Steffen Emmert, Holger A. Haenssle, John R. Zibert, Margarete Schön, Andreas Hald, Maria H. Hansen, Thomas Litman, Michael P. Schön |
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| E-Jahr: | 2016 |
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| Jahr: | 9 September 2016 |
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| Fussnoten: | Gesehen am 02.01.2018 |
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| Titel Quelle: | Enthalten in: PLOS ONE |
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| Ort Quelle: | San Francisco, California, US : PLOS, 2006 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 11(2016,9) Artikel-Nummer e0160096, 20 Seiten |
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| ISSN Quelle: | 1932-6203 |
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| Abstract: | The rapid and strong clinical efficacy of the first-in-class, ingenol mebutate, against actinic keratosis (AK) has resulted in its recent approval. We conducted the first comprehensive analysis of the cellular and molecular mode of action of topical ingenol mebutate 0.05% gel in both AK and uninvolved skin of 26 patients in a phase I, single-center, open-label, within-patient comparison. As early as 1 day after application, ingenol mebutate induced profound epidermal cell death, along with a strong infiltrate of CD4+ and CD8+ T-cells, neutrophils, and macrophages. Endothelial ICAM-1 activation became evident after 2 days. The reaction pattern was significantly more pronounced in AK compared with uninvolved skin, suggesting a tumor-preferential mode of action. Extensive molecular analyses and transcriptomic profiling of mRNAs and microRNAs demonstrated alterations in gene clusters functionally associated with epidermal development, inflammation, innate immunity, and response to wounding. Ingenol mebutate reveals a unique mode of action linking directly to anti-tumoral effects. Trial Registration: ClinicalTrials.gov NCT01387711 |
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| DOI: | doi:10.1371/journal.pone.0160096 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: http://dx.doi.org/10.1371/journal.pone.0160096 |
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| | kostenfrei: Volltext: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160096 |
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| | DOI: https://doi.org/10.1371/journal.pone.0160096 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Lesions |
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| | Biopsy |
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| | Cell death |
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| | Dermis |
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| | Epidermis |
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| | Gene expression |
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| | Inflammation |
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| | MicroRNAs |
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| K10plus-PPN: | 1566799120 |
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| Verknüpfungen: | → Zeitschrift |
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Tumor-preferential induction of immune responses and epidermal cell death in actinic keratoses by ingenol mebutate / Emmert, Steffen [VerfasserIn]; 9 September 2016 (Online-Ressource)
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