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Status: Bibliographieeintrag

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Verfasst von:Poustka, Luise [VerfasserIn]   i
 Schmidt, Martin H. [VerfasserIn]   i
 Brandeis, Daniel [VerfasserIn]   i
 Banaschewski, Tobias [VerfasserIn]   i
 Laucht, Manfred [VerfasserIn]   i
Titel:Interacting effects of maternal responsiveness, infant regulatory problems and dopamine D4 receptor gene in the development of dysregulation during childhood
Titelzusatz:A longitudinal analysis
Verf.angabe:Luise Poustka, Katrin Zohsel, Dorothea Blomeyer, Christine Jennen-Steinmetz, Brigitte Schmid, Patricia Trautmann-Villalba, Sarah Hohmann, Katja Becker, Günter Esser, Martin H. Schmidt, Daniel Brandeis, Tobias Banaschewski, Manfred Laucht
E-Jahr:2015
Jahr:November 2015
Umfang:8 S.
Fussnoten:Gesehen am 09.01.2018
Titel Quelle:Enthalten in: Journal of psychiatric research
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1961
Jahr Quelle:2015
Band/Heft Quelle:70(2015), Seite 83-90
ISSN Quelle:1879-1379
Abstract:Recent longitudinal studies have indicated that affective and behavioral dysregulation in childhood is associated with an increased risk for various negative outcomes in later life. However, few studies to date have examined early mechanisms preceding dysregulation during early childhood. Aim of this study was to elucidate early mechanisms relating to dysregulation in later life using data from an epidemiological cohort study on the long-term outcome of early risk factors from birth to adulthood. At age 3 months, mothers and infants were videotaped during a nursing and playing situation. Maternal responsiveness was evaluated by trained raters. Infant regulatory problems were assessed on the basis of a parent interview and direct observation by trained raters. At age 8 and 11 years, 290 children (139 males) were rated on the Child Behavior Checklist (CBCL). Additionally, participants were genotyped for the dopamine D4 receptor (DRD4) exon 3 VNTR polymorphism. A significant three-way interaction between maternal responsiveness, DRD4 genotype and infant regulatory problems was detected predicting the CBCL-dysregulation profile (CBCL-DP). Carriers of the DRD4 7r allele with regulatory problems at age 3 months showed significantly more behavior problems associated with the CBCL-DP during childhood when exposed to less maternal responsiveness. In contrast, no effect of maternal responsiveness was observed in DRD4 7r carriers without infant regulatory problems and in non-carriers of the DRD4 7r allele. This prospective longitudinal study extends earlier findings regarding the association of the CBCL-DP with early parenting and later psychopathology, introducing both DRD4 genotype and infant regulatory problems as important moderators.
DOI:doi:10.1016/j.jpsychires.2015.08.018
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.jpsychires.2015.08.018
 Volltext: http://www.sciencedirect.com/science/article/pii/S0022395615002605
 DOI: https://doi.org/10.1016/j.jpsychires.2015.08.018
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Childhood
 Dysregulation
 Gene-environment interaction
 Infant regulatory problems
 Parenting quality
K10plus-PPN:1566997208
Verknüpfungen:→ Zeitschrift

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