| |  Online-Ressource |
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| Verfasst von: | Schneider, Thomas [VerfasserIn]  |
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| | Heußel, Claus Peter [VerfasserIn] |
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| | Umansky, Ludmila [VerfasserIn] |
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| | Beckhove, Philipp [VerfasserIn] |
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| | Dienemann, Hendrik [VerfasserIn] |
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| | Safi, Seyer [VerfasserIn] |
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| | Utikal, Jochen [VerfasserIn] |
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| | Hoffmann, Hans [VerfasserIn] |
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| | Umansky, Viktor [VerfasserIn] |
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| Titel: | Serum inflammatory factors and circulating immunosuppressive cells are predictive markers for efficacy of radiofrequency ablation in non-small-cell lung cancer |
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| Verf.angabe: | T. Schneider, A. Sevko, C.P. Heussel, L. Umansky, P. Beckhove, H. Dienemann, S. Safi, J. Utikal, H. Hoffmann and V. Umansky |
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| E-Jahr: | 2015 |
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| Jahr: | June 2015 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 11.01.2018 |
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| Titel Quelle: | Enthalten in: Clinical & experimental immunology |
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| Ort Quelle: | Oxford : Wiley-Blackwell, 1966 |
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| Jahr Quelle: | 2015 |
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| Band/Heft Quelle: | 180(2015), 3, Seite 467-474 |
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| ISSN Quelle: | 1365-2249 |
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| Abstract: | In recent years, percutaneous radiofrequency ablation (RFA) has been developed as a new tool in the treatment of non-small-cell lung cancer (NSCLC) in non-surgical patients. There is growing evidence that RFA-mediated necrosis can modulate host immune responses. Here we analysed serum inflammatory factors as well as immunosuppressive cells in the peripheral blood to discover possible prognostic indicators. Peripheral blood and serum samples were collected before RFA and within 3 months after the treatment in a total of 12 patients. Inflammatory cytokines and growth factors were measured in serum by the Bio-Plex assay. Myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) were evaluated in the peripheral blood via flow cytometry. In patients developing local or lymphogenic tumour relapse (n = 4), we found an early significant increase in the concentration of tumour necrosis factor (TNF)-α as well as chemokine (C-C motif) ligand (CCL)-2 and CCL-4 compared to patients without relapse (n = 4) and healthy donors (n = 5). These changes were associated with an elevated activity of circulating MDSC indicated by an increased nitric oxide (NO) production in these cells. Elevated serum levels of TNF-α, CCL-2 and CCL-4 associated with an increased NO production in circulating MDSCs might be an early indicator of the incomplete RFA and subsequently a potential tumour relapse in NSCLC. |
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| DOI: | doi:10.1111/cei.12596 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
teilw. kostenfrei: Volltext: http://dx.doi.org/10.1111/cei.12596 |
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| | teilw. kostenfrei: Volltext: http://onlinelibrary.wiley.com.ezproxy.medma.uni-heidelberg.de/doi/10.1111/cei.12596/abstract |
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| | DOI: https://doi.org/10.1111/cei.12596 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | chronic inflammatory factors |
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| | myeloid-derived suppressor cells |
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| | non-small-cell lung cancer |
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| | radiofrequency ablation |
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| K10plus-PPN: | 156706244X |
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| Verknüpfungen: | → Zeitschrift |
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Serum inflammatory factors and circulating immunosuppressive cells are predictive markers for efficacy of radiofrequency ablation in non-small-cell lung cancer / Schneider, Thomas [VerfasserIn]; June 2015 (Online-Ressource)
